OPTN and RAB11A

Number of citations of the paper that reports this interaction (PMID 16905101)
18

Data Source:
BioGRID (two hybrid, x-ray crystallography, two hybrid, affinity chromatography technology, pull down)

		OPTN	RAB11A
Gene Name		optineurin	RAB11A, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome	Spindle Pole Mitochondrion Multivesicular Body Trans-Golgi Network Kinetochore Microtubule Cytosol Plasma Membrane Transport Vesicle Axon Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cleavage Furrow Protein Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding Syntaxin Binding Myosin V Binding
	Biological Process	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation	Cytokinesis Renal Water Homeostasis Water Transport Intracellular Protein Transport Exocytosis Organelle Organization Mitotic Metaphase Plate Congression Positive Regulation Of Epithelial Cell Migration Regulation Of Multivesicular Body Size Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Astral Microtubule Organization Neuron Projection Development Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Assembly Positive Regulation Of Axon Extension Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Protein Transport Establishment Of Vesicle Localization Transmembrane Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization To Organelle Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Mitotic Spindle Assembly Exosomal Secretion
Pathways		G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Vasopressin regulates renal water homeostasis via Aquaporins Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Aquaporin-mediated transport Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670	28 interactors: CHMP1B CHMP3 DTNBP1 GDI2 IKBKG KAT2B MYO5A MYO5B OPTN PPP2R1A PPP2R1B PSEN1 PSEN2 PTGIR RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP4 RAB11FIP5 RAB3IL1 RABGGTB RCHY1 SEC13 STX4 TBXA2R TDP2 WDR44 YWHAG
Entrez ID		10133	8766
HPRD ID		03891	05715
Ensembl ID		ENSG00000123240	ENSG00000103769
Uniprot IDs		Q96CV9	P62491
PDB IDs		2LO4 2LUE 3VTV 3VTW	1OIV 1OIW 1OIX 1YZK 2D7C 2GZD 2GZH 2HV8 4C4P
Enriched GO Terms of Interacting Partners?		Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction	Protein Transport Establishment Of Protein Localization Protein Localization Establishment Of Localization In Cell Cellular Localization Organelle Localization Vesicle-mediated Transport Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Transport Exocytosis Regulation Of Signal Transduction Post-Golgi Vesicle-mediated Transport Membrane Organization Intracellular Transport Regulation Of Signaling Golgi Vesicle Transport Cell Death Death Insulin Secretion Secretion By Cell Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Synaptic Transmission Negative Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulated Secretory Pathway Regulation Of Synaptic Plasticity Regulation Of Body Fluid Levels Amyloid Precursor Protein Catabolic Process Cell-cell Signaling Peptide Hormone Secretion Secretion Peptide Secretion Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Apoptotic Process Cell Cycle Cell Communication Negative Regulation Of Protein Kinase Activity Programmed Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Cycle Process Negative Regulation Of Kinase Activity Hormone Secretion Regulation Of Protein Kinase Activity Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process
Tagcloud ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto	c2 compartments displays fip fip1 fip2 fip3 fip5 fips gtpases hela illumination integral lactc2 live membranes microscopy overlap overlapped overlapping pericentriolar phosphatidylserine probe ps recycling structured tubular
Tagcloud (Difference) ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto	c2 compartments displays fip fip1 fip2 fip3 fip5 fips gtpases hela illumination integral lactc2 live membranes microscopy overlap overlapped overlapping pericentriolar phosphatidylserine probe ps recycling structured tubular
Tagcloud (Intersection) ?