CLTC and NCALD

Number of citations: 42 (PubMedID 11964161)
Data Source: HPRD (in vitro, in vivo)

		CLTC	NCALD
Name		clathrin heavy chain	neurocalcin delta
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Trans-Golgi Network Spindle Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule	Cytosol Clathrin Coat Of Trans-Golgi Network Vesicle
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding	Actin Binding Calcium Ion Binding Protein Binding Tubulin Binding Clathrin Binding Alpha-tubulin Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Vesicle-mediated Transport Receptor Internalization Transferrin Transport Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Regulation Of Mitotic Spindle Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane	Regulation Of Systemic Arterial Blood Pressure Regulation Of Signal Transduction Vesicle-mediated Transport Calcium-mediated Signaling
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance RHOU GTPase cycle RHOV GTPase cycle ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Activation of Ca-permeable Kainate Receptor
GWAS		No GWAS studies recorded	Age-related hearing impairment ( 24939585 ) Cerebral amyloid angiopathy ( 25188341 ) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682 ) Coffee consumption ( 21876539 ) Cognitive performance ( 20125193 ) Coronary artery disease ( 33020668 ) Gait speed in old age ( 28077804 ) LDL peak particle diameter (total fat intake interaction) ( 26112879 ) Medication use (beta blocking agents) ( 31015401 ) Microalbuminuria ( 26631737 ) Perceived sweetness of sucrose ( 31005972 ) Red cell distribution width ( 32888494 ) Systolic blood pressure ( 30224653 )
Interacting Genes		70 interacting genes: ACO1 AFTPH AMPH ANXA1 AP1B1 AP1G1 AP3B1 AP3B2 ARF6 ARMCX3 ARR3 ARRB1 ARRB2 BTG3 C10orf88 CEBPA CLINT1 CLTA CLTB DNAJC6 DSCAM DSCR9 DUX4 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 MAU2 NCALD NDRG1 OCRL OPTN PICALM PPP1CC PRKACA PXN QARS1 RIPK4 SCYL2 SMAP1 SNX5 SNX9 SPATC1L SRC STAMBP SUMO2 SYNJ1 TFAP2A TNK2 TOM1 USP7 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9	33 interacting genes: ACTB ANOS1 APOL3 C19orf44 C1QTNF2 CLTC CREM DTX2 FGF6 FZD7 GOLGA7 GPX7 IGFBP6 KRT6A LCE2D LIF LITAF LY6G6D MEOX2 MICOS10-NBL1 MIEF2 MLLT10 MYDGF NBL1 PLAAT2 PNP SBSN SPRED1 SRGN TMEM14B TPSG1 TUBA4A TUBB
Entrez ID		1213	83988
HPRD ID		00350	09466
Ensembl ID		ENSG00000141367	ENSG00000104490
Uniprot IDs		A0A087WVQ6 Q00610	B2RB70 P61601
PDB IDs		2XZG 4G55 6E4L 6QNN 6QNP 7BN1 7BN2 7ZX4 9C0Y 9C0Z	Not available
GO Terms Enriched among Interactors		Endocytosis Clathrin Binding Vesicle-mediated Transport Import Into Cell Clathrin-coated Vesicle Cytoplasmic Vesicle Clathrin-coated Pit Receptor-mediated Endocytosis Early Endosome Synaptic Vesicle Endocytosis Regulation Of Vesicle-mediated Transport Cytosol Presynaptic Endocytosis Endosome Establishment Of Localization In Cell Intracellular Transport Regulation Of Endocytosis Clathrin-dependent Endocytosis Regulation Of Receptor-mediated Endocytosis Cellular Localization Establishment Of Protein Localization Clathrin Vesicle Coat Clathrin Coat Assembly Clathrin Heavy Chain Binding Phosphatidylinositol Binding Protein Transport Protein Localization To Cell Surface Intracellular Protein Localization Cytoplasm Vesicle-mediated Transport In Synapse Clathrin-coated Vesicle Membrane Regulation Of Transport Clathrin Coat Of Coated Pit Early Endosome Membrane Receptor Internalization Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Membrane Presynapse Phospholipid Binding Regulation Of Clathrin Coat Assembly Synaptic Vesicle Uncoating Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Endosomal Transport Membrane Coat Perinuclear Region Of Cytoplasm Protein Domain Specific Binding Positive Regulation Of Cellular Component Organization Clathrin Coat Disassembly Clathrin Adaptor Activity	Extracellular Region Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Structural Constituent Of Cytoskeleton Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Maintenance Of Protein Location Extracellular Space Protein Binding Maintenance Of Location