OPTN and ENTREP1

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		OPTN	ENTREP1
Description		optineurin	endosomal transmembrane epsin interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane	Endosome Plasma Membrane Membrane Early Endosome Membrane Late Endosome Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Receptor Recycling Immune System Process Autophagy Golgi Organization Signal Transduction Intracellular Protein Localization Cell Death Positive Regulation Of Autophagy Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Defense Response To Gram-negative Bacterium Type 2 Mitophagy Golgi Ribbon Formation Positive Regulation Of Xenophagy	Negative Adaptation Of Signaling Pathway Receptor Internalization CXCL12-activated CXCR4 Signaling Pathway
Pathways		Regulation of PLK1 Activity at G2/M Transition PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TBC/RABGAPs TICAM1-dependent activation of IRF3/IRF7 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 20436471 21623375)
Interacting Genes		72 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CFTR CLTC CMYA5 DAZAP2 DYSF DZIP1 ENTREP1 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAILR MAP1LC3A MAP1LC3B MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNCA SNX6 TBC1D15 TBC1D17 UBB UQCRQ USP2 VCP WASHC3 WIPI2 WWP2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711	11 interacting genes: BAG3 CALCOCO2 NEDD4 OPTN SFN STAM2 TAX1BP1 UBQLN1 UBXN1 WWP1 WWP2
Entrez ID		10133	9413
HPRD ID		03891	16255
Ensembl ID		ENSG00000123240	ENSG00000135063
Uniprot IDs		Q96CV9	Q15884 Q8WU02
PDB IDs		2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF 7CZM 9B0B 9B0Z 9B12 9IKQ
Enriched GO Terms of Interacting Partners?		Autophagosome Cellular Response To Nitrogen Starvation Cytoplasmic Vesicle Phosphatidylethanolamine Binding Autophagy Autophagosome Maturation Endosome Autophagosome Assembly Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagy Of Mitochondrion Establishment Of Protein Localization Macroautophagy Protein Transport Phospholipid Binding Autophagosome Membrane Vacuole Organization Mitophagy Myosin V Binding Cellular Response To Starvation Establishment Of Localization In Cell Recycling Endosome Membrane Protein-containing Complex Disassembly Response To Starvation Organelle Assembly Intracellular Transport Recycling Endosome Cellular Response To Nutrient Levels Intracellular Protein Localization Endosomal Transport Cellular Localization Lysosome Beta-tubulin Binding Centriolar Satellite Amyloid-beta Clearance By Transcytosis Response To Iron(II) Ion Regulation Of Cilium Assembly Vesicle-mediated Transport Cellular Response To Stress Cytoplasmic Vesicle Membrane Cytosol G Protein Activity Cytoplasm Intracellular Protein Transport Endocytic Recycling Regulation Of Protein Localization Exocytosis Endosome Membrane Catabolic Process Response To Nutrient Levels	Catabolic Process Autophagy Regulation Of Macroautophagy Autophagosome Polyubiquitin Modification-dependent Protein Binding Regulation Of Autophagy Macroautophagy Cytosol Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cation Transmembrane Transport Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Potassium Channel Inhibitor Activity Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transmembrane Transport Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Macroautophagy Negative Regulation Of Monoatomic Ion Transport Ubiquitin Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin Ligase Complex Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport Cytoplasm Cellular Response To Unfolded Protein Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Intracellular Transport Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Cellular Response To Topologically Incorrect Protein Negative Regulation Of Potassium Ion Transport Positive Regulation Of Autophagy Proteasomal Protein Catabolic Process Aggresome Regulation Of Protein Export From Nucleus Intracellular Protein Transport Protein-macromolecule Adaptor Activity Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Transport Intracellular Protein Localization Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Organelle Proteolysis Regulation Of Monoatomic Cation Transmembrane Transport
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