OPTN and ZNF329

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OPTN	ZNF329
Gene Name		optineurin	zinc finger protein 329
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome	Nucleus
	Molecular Function	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding	DNA Binding Metal Ion Binding
	Biological Process	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670	11 interactors: CEP70 KRT40 KRTAP10-1 KRTAP10-5 KRTAP10-7 MEOX2 MTUS2 OPTN SMAD3 TRIM37 TRIM41
Entrez ID		10133	79673
HPRD ID		03891	07779
Ensembl ID		ENSG00000123240	ENSG00000181894
Uniprot IDs		Q96CV9	Q86UD4
PDB IDs		2LO4 2LUE 3VTV 3VTW
Enriched GO Terms of Interacting Partners?		Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction	Somitogenesis Embryonic Pattern Specification Somite Development Positive Regulation Of Transforming Growth Factor Beta3 Production Segmentation G2/M Transition Of Mitotic Cell Cycle Evasion Or Tolerance Of Host Defenses By Virus Histone H2A-K119 Monoubiquitination Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Receptor Recycling Regulation Of Extracellular Matrix Assembly Negative Regulation Of Centriole Replication Primary MiRNA Processing Somite Specification Cell Cycle Process Cell Death Death Anterior/posterior Pattern Specification Golgi Ribbon Formation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Transdifferentiation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Alkaline Phosphatase Activity Regulation Of Centriole Replication Histone H2A Monoubiquitination Aggresome Assembly Paraxial Mesoderm Morphogenesis Cell Cycle Histone H2A Ubiquitination Nodal Signaling Pathway Negative Regulation Of Centrosome Duplication Positive Regulation Of Transforming Growth Factor Beta Production Segment Specification Regulation Of Osteoblast Proliferation Negative Regulation Of Cell Cycle Histone Monoubiquitination Embryonic Foregut Morphogenesis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Production Of MiRNAs Involved In Gene Silencing By MiRNA Foregut Morphogenesis Pattern Specification Process Modulation By Virus Of Host Morphology Or Physiology Paraxial Mesoderm Development
Tagcloud ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Difference) ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Intersection) ?