OPTN and RAB14

Number of citations of the paper that reports this interaction (PMID 19702578)
17

Data Source:
BioGRID (two hybrid)

		OPTN	RAB14
Gene Name		optineurin	RAB14, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome	Golgi Membrane Intracellular Lysosome Lysosomal Membrane Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding
	Biological Process	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation	Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Vesicle-mediated Transport Endocytic Recycling Rab Protein Signal Transduction Regulation Of Protein Localization Intracellular Transport Membrane Organization Phagolysosome Assembly Involved In Apoptotic Cell Clearance
Pathways		G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic	Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Paget's disease ( 21623375 20436471)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670	9 interactors: APP CHM EXOC5 OCRL OPTN RAB11FIP5 RBSN RUFY1 SMURF2
Entrez ID		10133	51552
HPRD ID		03891	06693
Ensembl ID		ENSG00000123240	ENSG00000119396
Uniprot IDs		Q96CV9	P61106
PDB IDs		2LO4 2LUE 3VTV 3VTW	1Z0F 4DRZ
Enriched GO Terms of Interacting Partners?		Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction	Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Exocytosis Protein Localization Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Cellular Localization Secretion By Cell Synaptic Growth At Neuromuscular Junction Intracellular Transport Secretion Collateral Sprouting In Absence Of Injury Negative Regulation Of Receptor Recycling Transport Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Insulin Secretion Involved In Cellular Response To Glucose Stimulus Axon Choice Point Recognition Golgi Ribbon Formation Ubiquitin-dependent SMAD Protein Catabolic Process Membrane Organization Cellular Response To Acidic PH Protein Geranylgeranylation Establishment Of Protein Localization To Membrane Neuron Remodeling Golgi Vesicle Transport Positive Regulation Of Hydrolase Activity
Tagcloud ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto	a2 abundantly alveolar annexin bodies details egfp immunoprecipitated indeed interference lamellar localized microarray nevertheless overexpressing phospholipid regulated rescued returned secretion selected silenced silencing surfactant tagged targets thirteen transcriptome validated
Tagcloud (Difference) ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto	a2 abundantly alveolar annexin bodies details egfp immunoprecipitated indeed interference lamellar localized microarray nevertheless overexpressing phospholipid regulated rescued returned secretion selected silenced silencing surfactant tagged targets thirteen transcriptome validated
Tagcloud (Intersection) ?