CLTC and AP3B2

Number of citations of the paper that reports this interaction (PubMedID 9545220)
0

Data Source:
HPRD (in vitro)

		CLTC	AP3B2
Description		clathrin heavy chain	adaptor related protein complex 3 subunit beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Trans-Golgi Network Spindle Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule	Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Intracellular Vesicle Presynapse Axon Cytoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding
	Biological Process	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Vesicle-mediated Transport Receptor Internalization Transferrin Transport Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Regulation Of Mitotic Spindle Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane	Intracellular Protein Transport Anterograde Axonal Transport Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Synaptic Vesicle Endocytosis Anterograde Synaptic Vesicle Transport
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance RHOU GTPase cycle RHOV GTPase cycle ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS			Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Schizophrenia ( 28991256) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		70 interacting genes: ACO1 AFTPH AMPH ANXA1 AP1B1 AP1G1 AP3B1 AP3B2 ARF6 ARMCX3 ARR3 ARRB1 ARRB2 BTG3 C10orf88 CEBPA CLINT1 CLTA CLTB DNAJC6 DSCAM DSCR9 DUX4 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 MAU2 NCALD NDRG1 OCRL OPTN PICALM PPP1CC PRKACA PXN QARS1 RIPK4 SCYL2 SMAP1 SNX5 SNX9 SPATC1L SRC STAMBP SUMO2 SYNJ1 TFAP2A TNK2 TOM1 USP7 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9	7 interacting genes: ADAP1 AP3S1 ATM CLTC CSNK1A1 ERBB2 RUFY1
Entrez ID		1213	8120
HPRD ID		00350	03699
Ensembl ID		ENSG00000141367	ENSG00000103723
Uniprot IDs		A0A087WVQ6 Q00610	F5GYB0 Q13367
PDB IDs		2XZG 4G55 6E4L 6QNN 6QNP 7BN1 7BN2 7ZX4 9C0Y 9C0Z
Enriched GO Terms of Interacting Partners?		Endocytosis Clathrin Binding Vesicle-mediated Transport Import Into Cell Clathrin-coated Vesicle Cytoplasmic Vesicle Clathrin-coated Pit Receptor-mediated Endocytosis Early Endosome Synaptic Vesicle Endocytosis Regulation Of Vesicle-mediated Transport Cytosol Presynaptic Endocytosis Endosome Establishment Of Localization In Cell Intracellular Transport Regulation Of Endocytosis Clathrin-dependent Endocytosis Regulation Of Receptor-mediated Endocytosis Cellular Localization Establishment Of Protein Localization Clathrin Vesicle Coat Clathrin Coat Assembly Clathrin Heavy Chain Binding Phosphatidylinositol Binding Protein Transport Protein Localization To Cell Surface Intracellular Protein Localization Cytoplasm Vesicle-mediated Transport In Synapse Clathrin-coated Vesicle Membrane Regulation Of Transport Clathrin Coat Of Coated Pit Early Endosome Membrane Receptor Internalization Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Membrane Presynapse Phospholipid Binding Regulation Of Clathrin Coat Assembly Synaptic Vesicle Uncoating Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Endosomal Transport Membrane Coat Perinuclear Region Of Cytoplasm Protein Domain Specific Binding Positive Regulation Of Cellular Component Organization Clathrin Coat Disassembly Clathrin Adaptor Activity	Intracellular Membrane-bounded Organelle Positive Regulation Of Rho Protein Signal Transduction Spindle Establishment Of RNA Localization To Telomere Autophagosome Assembly Negative Regulation Of TOR Signaling Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of TORC1 Signaling Protein Phosphorylation Regulation Of TORC1 Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Leukocyte Proliferation Autophagosome Organization Negative Regulation Of Mononuclear Cell Proliferation Cytoplasmic Vesicle Positive Regulation Of Telomerase Catalytic Core Complex Assembly Phosphorylation Intracellular Protein Localization Protein Kinase Activity Retrograde Transport, Endosome To Golgi Regulation Of Rho Protein Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction ERBB3:ERBB2 Complex Regulation Of Cellular Component Organization DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Cytosolic Transport RNA Polymerase I Core Binding Vacuole Organization Negative Regulation Of Lymphocyte Activation Positive Regulation Of Autophagy Cellular Response To Nitrosative Stress Regulation Of TOR Signaling Peptidyl-serine Autophosphorylation Signal Transduction Kinase Activity Pre-B Cell Allelic Exclusion Cellular Localization AP-type Membrane Coat Adaptor Complex Synaptic Vesicle Coating Cytoplasmic Vesicle Membrane Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Disassembly Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Inositol 1,3,4,5 Tetrakisphosphate Binding Organelle Assembly
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