CLTC and HIP1

Number of citations: 0 (PubMedID 11532990)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		CLTC	HIP1
Name		clathrin heavy chain	huntingtin interacting protein 1
Structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Trans-Golgi Network Spindle Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Endomembrane System Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Cytoplasmic Vesicle Synapse Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding	Actin Binding Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Vesicle-mediated Transport Receptor Internalization Transferrin Transport Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Regulation Of Mitotic Spindle Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane	Endocytosis Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance RHOU GTPase cycle RHOV GTPase cycle ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Clathrin-mediated endocytosis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
GWAS		No GWAS studies recorded	Age-related nuclear cataracts ( 24951543 ) Alcoholism (12-month weekly alcohol consumption) ( 21529783 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body mass index ( 26961502 28448500 28892062 25673413 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Interleukin-6 levels ( 22205395 ) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309 ) Systemic lupus erythematosus ( 26663301 ) White blood cell count (basophil) ( 27863252 )
Interacting Genes		70 interacting genes: ACO1 AFTPH AMPH ANXA1 AP1B1 AP1G1 AP3B1 AP3B2 ARF6 ARMCX3 ARR3 ARRB1 ARRB2 BTG3 C10orf88 CEBPA CLINT1 CLTA CLTB DNAJC6 DSCAM DSCR9 DUX4 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 MAU2 NCALD NDRG1 OCRL OPTN PICALM PPP1CC PRKACA PXN QARS1 RIPK4 SCYL2 SMAP1 SNX5 SNX9 SPATC1L SRC STAMBP SUMO2 SYNJ1 TFAP2A TNK2 TOM1 USP7 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9	37 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CFAP53 CLTA CLTB CLTC CYRIB DAZAP2 DVL2 EHHADH EIF6 FAM168A FBXO25 HIP1R HTT IFT57 ITSN1 LITAF LNX1 MAP3K1 MAPK6 NECAP1 PFDN1 RAD23B REL RPRM RPS10 SMURF1 SYT17 TCEA2 TCEANC TFAP2A UBC
Entrez ID		1213	3092
HPRD ID		00350	03461
Ensembl ID		ENSG00000141367	ENSG00000127946
Uniprot IDs		A0A087WVQ6 Q00610	B4DK46 O00291
PDB IDs		2XZG 4G55 6E4L 6QNN 6QNP 7BN1 7BN2 7ZX4 9C0Y 9C0Z	2NO2 2QA7 3I00
GO Terms Enriched among Interactors		Endocytosis Clathrin Binding Vesicle-mediated Transport Import Into Cell Clathrin-coated Vesicle Cytoplasmic Vesicle Clathrin-coated Pit Receptor-mediated Endocytosis Early Endosome Synaptic Vesicle Endocytosis Regulation Of Vesicle-mediated Transport Cytosol Presynaptic Endocytosis Endosome Establishment Of Localization In Cell Intracellular Transport Regulation Of Endocytosis Clathrin-dependent Endocytosis Regulation Of Receptor-mediated Endocytosis Cellular Localization Establishment Of Protein Localization Clathrin Vesicle Coat Clathrin Coat Assembly Clathrin Heavy Chain Binding Phosphatidylinositol Binding Protein Transport Protein Localization To Cell Surface Intracellular Protein Localization Cytoplasm Vesicle-mediated Transport In Synapse Clathrin-coated Vesicle Membrane Regulation Of Transport Clathrin Coat Of Coated Pit Early Endosome Membrane Receptor Internalization Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Membrane Presynapse Phospholipid Binding Regulation Of Clathrin Coat Assembly Synaptic Vesicle Uncoating Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Endosomal Transport Membrane Coat Perinuclear Region Of Cytoplasm Protein Domain Specific Binding Positive Regulation Of Cellular Component Organization Clathrin Coat Disassembly Clathrin Adaptor Activity	Clathrin-coated Pit Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin Coat Presynaptic Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Endolysosome Membrane Receptor-mediated Endocytosis Clathrin Coat Assembly Response To Anesthetic Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin Vesicle Coat Response To Cobalt Ion Endocytosis Presynaptic Endocytic Zone Membrane Clathrin Adaptor Activity Apoptosome Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Hyaluronan Biosynthetic Process Protein-containing Complex Import Into Cell Tube Closure Glial Cell Apoptotic Process Cytoplasmic Vesicle Regulation Of Hyaluronan Biosynthetic Process Death-inducing Signaling Complex Clathrin Light Chain Binding Cytosol Vesicle-mediated Transport Postsynaptic Neurotransmitter Receptor Internalization Clathrin Complex Protein Binding Intracellular Transport Positive Regulation Of Pyroptotic Inflammatory Response Tube Formation Clathrin Heavy Chain Binding AP-2 Adaptor Complex Fibroblast Apoptotic Process Establishment Of Localization In Cell Cytoplasm Clathrin Adaptor Complex Cysteine-type Endopeptidase Activity Protein Kinase Binding Clathrin-coated Endocytic Vesicle Membrane Kidney Development Receptor Internalization