CLTC and MAP3K10

Number of citations: 0 (PubMedID 12105200)
Data Source: HPRD (in vitro)

		CLTC	MAP3K10
Name		clathrin heavy chain	mitogen-activated protein kinase kinase kinase 10
Structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Trans-Golgi Network Spindle Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule	Cytoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding	Nucleotide Binding Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Vesicle-mediated Transport Receptor Internalization Transferrin Transport Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Regulation Of Mitotic Spindle Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance RHOU GTPase cycle RHOV GTPase cycle ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	None
Drugs		None	Fostamatinib
GWAS		No GWAS studies recorded	Birth weight ( 31043758 ) Resting heart rate ( 27798624 )
Interacting Genes		70 interacting genes: ACO1 AFTPH AMPH ANXA1 AP1B1 AP1G1 AP3B1 AP3B2 ARF6 ARMCX3 ARR3 ARRB1 ARRB2 BTG3 C10orf88 CEBPA CLINT1 CLTA CLTB DNAJC6 DSCAM DSCR9 DUX4 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 MAU2 NCALD NDRG1 OCRL OPTN PICALM PPP1CC PRKACA PXN QARS1 RIPK4 SCYL2 SMAP1 SNX5 SNX9 SPATC1L SRC STAMBP SUMO2 SYNJ1 TFAP2A TNK2 TOM1 USP7 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9	31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 LCOR MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB1 RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE
Entrez ID		1213	4294
HPRD ID		00350	02533
Ensembl ID		ENSG00000141367	ENSG00000130758
Uniprot IDs		A0A087WVQ6 Q00610	Q02779
PDB IDs		2XZG 4G55 6E4L 6QNN 6QNP 7BN1 7BN2 7ZX4 9C0Y 9C0Z	2RF0
GO Terms Enriched among Interactors		Endocytosis Clathrin Binding Vesicle-mediated Transport Import Into Cell Clathrin-coated Vesicle Cytoplasmic Vesicle Clathrin-coated Pit Receptor-mediated Endocytosis Early Endosome Synaptic Vesicle Endocytosis Regulation Of Vesicle-mediated Transport Cytosol Presynaptic Endocytosis Endosome Establishment Of Localization In Cell Intracellular Transport Regulation Of Endocytosis Clathrin-dependent Endocytosis Regulation Of Receptor-mediated Endocytosis Cellular Localization Establishment Of Protein Localization Clathrin Vesicle Coat Clathrin Coat Assembly Clathrin Heavy Chain Binding Phosphatidylinositol Binding Protein Transport Protein Localization To Cell Surface Intracellular Protein Localization Cytoplasm Vesicle-mediated Transport In Synapse Clathrin-coated Vesicle Membrane Regulation Of Transport Clathrin Coat Of Coated Pit Early Endosome Membrane Receptor Internalization Intracellular Protein Transport Golgi Apparatus Cytoplasmic Vesicle Membrane Presynapse Phospholipid Binding Regulation Of Clathrin Coat Assembly Synaptic Vesicle Uncoating Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Endosomal Transport Membrane Coat Perinuclear Region Of Cytoplasm Protein Domain Specific Binding Positive Regulation Of Cellular Component Organization Clathrin Coat Disassembly Clathrin Adaptor Activity	MAPK Cascade Kinesin II Complex Protein Phosphatase Binding Cytoplasm Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction Dendrite Cytoplasm Signal Transduction Intracellular Signaling Cassette Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Cytosol Organelle Transport Along Microtubule Regulation Of Multicellular Organismal Process Transport Along Microtubule Nucleotide Binding Anterograde Dendritic Transport Regulation Of Cell Communication Regulation Of Signaling Endocytosis Extracellular Exosome Protein Kinase Binding Intracellular Protein Localization Cellular Localization Vesicle Transport Along Microtubule Kinesin Complex MAP-kinase Scaffold Activity Membrane Invagination Receptor Localization To Synapse Regulation Of Transport Regulation Of Immune System Process Microtubule Microtubule-based Transport MAP Kinase Activity Positive Regulation Of Cellular Component Organization Vesicle Cytoskeletal Trafficking Postsynapse Dendritic Transport Negative Regulation Of Signal Transduction JNK Cascade Cell Surface Receptor Signaling Pathway Mitotic Spindle Intracellular Transport Regulation Of Vesicle-mediated Transport Plus-end-directed Microtubule Motor Activity Microtubule Binding Microtubule Cytoskeleton Positive Regulation Of Leukocyte Migration