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OPTN and TBC1D17
Number of citations of the paper that reports this interaction (PubMedID
31723608
)
67
Data Source:
BioGRID
(two hybrid, proximity labelling technology, two hybrid, affinity chromatography technology, pull down)
HPRD
(two hybrid)
OPTN
TBC1D17
Description
optineurin
TBC1 domain family member 17
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Autophagosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Recycling Endosome
Recycling Endosome Membrane
Cytoplasm
Endosome
Autophagosome
Cytosol
Cytoplasmic Vesicle
Recycling Endosome
Molecular Function
Protein Binding
Zinc Ion Binding
Protein-macromolecule Adaptor Activity
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
GTPase Activator Activity
Protein Binding
Biological Process
Negative Regulation Of Receptor Recycling
Immune System Process
Autophagy
Golgi Organization
Signal Transduction
Intracellular Protein Localization
Cell Death
Positive Regulation Of Autophagy
Protein Localization To Golgi Apparatus
Cellular Response To Unfolded Protein
Golgi To Plasma Membrane Protein Transport
Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Defense Response To Gram-negative Bacterium
Type 2 Mitophagy
Golgi Ribbon Formation
Positive Regulation Of Xenophagy
Autophagy
Protein Transport
Retrograde Transport, Endosome To Golgi
Regulation Of Cilium Assembly
Pathways
Regulation of PLK1 Activity at G2/M Transition
PINK1-PRKN Mediated Mitophagy
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
TBC/RABGAPs
TICAM1-dependent activation of IRF3/IRF7
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
TBC/RABGAPs
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Primary open angle glaucoma
GWAS
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Paget's disease (
20436471
21623375
)
Interacting Genes
72 interacting genes:
AIMP1
ARRDC3
ATG16L1
ATG5
CALM1
CCDC13
CDC23
CFTR
CLTC
CMYA5
DAZAP2
DYSF
DZIP1
ENTREP1
FLII
FOS
FTH1
GABARAP
GABARAPL1
GABARAPL2
GNAS
GRM1
GTF3A
HACE1
HSF2BP
HSPB1
HTT
IRAK1
KANSL1L
LITAF
LNX2
MAILR
MAP1LC3A
MAP1LC3B
MAP1LC3C
MPP1
MYH3
MYO6
PIAS4
PICK1
POU6F2
RAB11A
RAB11B
RAB12
RAB14
RAB25
RAB8A
RBM12
RFFL
RNF11
RNF216
SDCBP
SLF2
SNCA
SNX6
TBC1D15
TBC1D17
UBB
UQCRQ
USP2
VCP
WASHC3
WIPI2
WWP2
ZNF17
ZNF181
ZNF302
ZNF329
ZNF398
ZNF426
ZNF670
ZNF711
20 interacting genes:
ASCC2
CALCOCO1
CCT5
CDKN2D
DHX29
FBL
GABARAPL1
GPS1
GTF3C1
MAP1LC3A
MAP1LC3B
NIPSNAP1
OPTN
RAB1A
RAB5A
RAB5B
RAB5C
SLC1A5
TAX1BP1
UBC
Entrez ID
10133
79735
HPRD ID
03891
15471
Ensembl ID
ENSG00000123240
ENSG00000104946
Uniprot IDs
Q96CV9
Q9HA65
PDB IDs
2LO4
2LUE
3VTV
3VTW
5AAZ
5B83
5EOA
5EOF
7CZM
9B0B
9B0Z
9B12
9IKQ
Enriched GO Terms of Interacting Partners
?
Autophagosome
Cellular Response To Nitrogen Starvation
Cytoplasmic Vesicle
Phosphatidylethanolamine Binding
Autophagy
Autophagosome Maturation
Endosome
Autophagosome Assembly
Ubiquitin Protein Ligase Binding
Autophagosome Organization
Autophagy Of Mitochondrion
Establishment Of Protein Localization
Macroautophagy
Protein Transport
Phospholipid Binding
Autophagosome Membrane
Vacuole Organization
Mitophagy
Myosin V Binding
Cellular Response To Starvation
Establishment Of Localization In Cell
Recycling Endosome Membrane
Protein-containing Complex Disassembly
Response To Starvation
Organelle Assembly
Intracellular Transport
Recycling Endosome
Cellular Response To Nutrient Levels
Intracellular Protein Localization
Endosomal Transport
Cellular Localization
Lysosome
Beta-tubulin Binding
Centriolar Satellite
Amyloid-beta Clearance By Transcytosis
Response To Iron(II) Ion
Regulation Of Cilium Assembly
Vesicle-mediated Transport
Cellular Response To Stress
Cytoplasmic Vesicle Membrane
Cytosol
G Protein Activity
Cytoplasm
Intracellular Protein Transport
Endocytic Recycling
Regulation Of Protein Localization
Exocytosis
Endosome Membrane
Catabolic Process
Response To Nutrient Levels
Mitophagy
Autophagy
Autophagy Of Mitochondrion
Autophagosome
Melanosome
Plasma Membrane To Endosome Transport
Cellular Response To Nitrogen Starvation
Endomembrane System
Phosphatidylethanolamine Binding
Macroautophagy
G Protein Activity
Autophagosome Assembly
Autophagosome Organization
Autophagosome Maturation
Autophagosome Membrane
Vacuole Organization
Endocytic Vesicle
GDP Binding
Catabolic Process
Extracellular Exosome
Cytoplasmic Vesicle
Ubiquitin Protein Ligase Binding
Phospholipid Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
GTPase Activity
Early Endosome
Import Into Cell
Microtubule
Protein-containing Complex Disassembly
GTP Binding
Beta-tubulin Binding
U6 SnRNA 2'-O-ribose Methyltransferase Activity
Organelle Assembly
Organelle Organization
Cellular Response To Starvation
Organelle Membrane
Endosome
Endocytosis
Early Endosome Membrane
Protein-macromolecule Adaptor Activity
Response To Nutrient Levels
Histone H2AQ104 Methyltransferase Activity
JNK Cascade
Glutamine Secretion
Protein Localization To Phagocytic Vesicle
Response To Starvation
Cyclin D2-CDK4 Complex
Box C/D Sno(s)RNA 3'-end Processing
Intracellular Protein Transport
Protein Localization To Early Endosome
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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