OPTN and TBC1D17

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology, pull down)
HPRD (two hybrid)

		OPTN	TBC1D17
Gene Name		optineurin	TBC1 domain family, member 17
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome	Autophagic Vacuole Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding	Rab GTPase Activator Activity Protein Binding
	Biological Process	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation	Autophagy Protein Transport Positive Regulation Of Rab GTPase Activity Retrograde Transport, Endosome To Golgi Regulation Of Cilium Assembly
Pathways		G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670	19 interactors: ASCC2 CALCOCO1 CCT5 CDKN2D DHX29 FBL GABARAPL1 GPS1 GTF3C1 MAP1LC3A MAP1LC3B NIPSNAP1 OPTN RAB1A RAB5A RAB5B RAB5C SLC1A5 TAX1BP1
Entrez ID		10133	79735
HPRD ID		03891	15471
Ensembl ID		ENSG00000123240	ENSG00000104946
Uniprot IDs		Q96CV9	Q9HA65
PDB IDs		2LO4 2LUE 3VTV 3VTW
Enriched GO Terms of Interacting Partners?		Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction	Macroautophagy Autophagic Vacuole Assembly Cellular Response To Starvation Rab Protein Signal Transduction Autophagy Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Nucleophagy Response To Nutrient Levels Response To Extracellular Stimulus Vacuole Organization Mitochondrion Degradation Organelle Disassembly Plasma Membrane To Endosome Transport Ras Protein Signal Transduction Response To External Stimulus Cellular Response To Nitrogen Starvation Cellular Response To Stress Membrane Fusion Cytoplasmic Transport Regulation Of Endocytosis Membrane Organization Organelle Assembly Response To Stimulus Endosomal Transport Intracellular Protein Transport Response To Stress Histone Glutamine Methylation Extracellular Amino Acid Transport Small GTPase Mediated Signal Transduction Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Peptidyl-glutamine Methylation Golgi Organization Response To Other Organism Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Response To Biotic Stimulus Regulation Of Vesicle-mediated Transport Interleukin-8 Production SnoRNA Metabolic Process Negative Regulation Of Receptor Recycling Cellular Protein Localization Mitochondrion Organization Protein Transport Negative Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Endomembrane System Organization 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter
Tagcloud ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Difference) ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto
Tagcloud (Intersection) ?