OPTN and RAB12

Number of citations of the paper that reports this interaction (PMID 23357852)
4

Data Source:
BioGRID (two hybrid)

		OPTN	RAB12
Gene Name		optineurin	RAB12, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagic Vacuole Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Membrane-bounded Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome	Golgi Membrane Lysosome Lysosomal Membrane Autophagic Vacuole Golgi Apparatus Endosome Membrane Insulin-responsive Compartment Recycling Endosome Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Rab GTPase Binding Polyubiquitin Binding K63-linked Polyubiquitin Binding	GTPase Activity GTP Binding GDP Binding
	Biological Process	Protein Targeting To Golgi G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Golgi Organization Signal Transduction Cell Death Macroautophagy Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Gram-negative Bacterium Golgi Ribbon Formation	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome To Lysosome Transport Protein Secretion Positive Regulation Of Macroautophagy Regulation Of Exocytosis Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Cellular Protein Catabolic Process Protein Localization To Plasma Membrane
Pathways		G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		36 interactors: CALM1 CCDC53 CDC23 CYLD DAZAP2 EPS15 FAM178A FLII FOS GNAS GRM1 GTF3A HACE1 HTT MAP1LC3A MPP1 MYO6 PIAS4 RAB10 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RNF11 SQSTM1 TBC1D15 TBC1D17 TBK1 TNIP1 UBC UQCRQ ZNF329 ZNF398 ZNF670	1 interactors: OPTN
Entrez ID		10133	201475
HPRD ID		03891	18749
Ensembl ID		ENSG00000123240	ENSG00000206418
Uniprot IDs		Q96CV9	Q6IQ22
PDB IDs		2LO4 2LUE 3VTV 3VTW	2IL1
Enriched GO Terms of Interacting Partners?		Endosomal Transport Rab Protein Signal Transduction Membrane Organization Ras Protein Signal Transduction Secretion By Cell Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Secretion Protein Secretion Cellular Localization Cell Communication Signal Transduction Regulation Of Signaling Protein Transport Vesicle-mediated Transport Signaling Establishment Of Protein Localization Exocytosis Protein Localization Pattern Recognition Receptor Signaling Pathway Cellular Response To Stimulus Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Intracellular Protein Transport Positive Regulation Of Metabolic Process Positive Regulation Of Innate Immune Response Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Cellular Protein Catabolic Process Regulation Of Vesicle-mediated Transport Melanosome Transport Regulation Of Intracellular Signal Transduction Pigment Granule Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor Signaling Pathway Establishment Of Melanosome Localization Protein Catabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Organelle Localization Melanosome Localization Endomembrane System Organization Golgi Vesicle Transport Negative Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction	Negative Regulation Of Receptor Recycling Golgi Ribbon Formation Protein Targeting To Golgi Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Receptor Recycling Golgi To Plasma Membrane Transport Defense Response To Gram-negative Bacterium Protein Localization To Golgi Apparatus Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intra-Golgi Vesicle-mediated Transport Macroautophagy Golgi Organization Establishment Of Protein Localization To Plasma Membrane Post-Golgi Vesicle-mediated Transport G2/M Transition Of Mitotic Cell Cycle Cellular Response To Starvation Protein Localization To Plasma Membrane Autophagy Cellular Response To Nutrient Levels Response To Starvation Defense Response To Bacterium Cellular Response To Extracellular Stimulus Plasma Membrane Organization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Establishment Of Protein Localization To Membrane Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Golgi Vesicle Transport Establishment Of Protein Localization To Organelle Protein Localization To Membrane Negative Regulation Of Intracellular Signal Transduction Protein Targeting Response To Nutrient Levels Endomembrane System Organization Response To Extracellular Stimulus Response To Bacterium
Tagcloud ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto	17p 20q 8p 8q aberration abhd12 abhd2 affymetrix arhgdib cna copy crc cxcl6 deployed integrating loc440995 oit3 omics organizing ralbp1 rnmt s1000a2 s100a2 sty sult1b1 tokyo tyms ugt2b28 written
Tagcloud (Difference) ?		advocate agenda ast cms comes competence consent continuum controversies educated ilda independence informed interpretive ldcop mandated maximize medicaid minimize narrow optimize procurement profession qualifications regulations skill transparent varies veto	17p 20q 8p 8q aberration abhd12 abhd2 affymetrix arhgdib cna copy crc cxcl6 deployed integrating loc440995 oit3 omics organizing ralbp1 rnmt s1000a2 s100a2 sty sult1b1 tokyo tyms ugt2b28 written
Tagcloud (Intersection) ?