CLIC1 and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (two hybrid)

		CLIC1	MYOC
Gene Name		chloride intracellular channel 1	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Chloride Transport Signal Transduction Regulation Of Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: AKAP9 ALOX5AP ATP5F1 ATP6V0A1 ATP6V0C CPT1A IKBKG LSM1 MYOC NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TRAPPC2 ZNF184 ZNF302	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		1192	4653
HPRD ID		04188	03387
Ensembl ID		ENSG00000213719	ENSG00000034971
Uniprot IDs		O00299 Q5SRT3	Q99972
PDB IDs		1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Cytoplasmic Sequestering Of Transcription Factor Gene Expression Cytoplasmic Sequestering Of Protein Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Localization Heterocycle Metabolic Process Transferrin Transport ATP Synthesis Coupled Proton Transport Hydrogen Ion Transmembrane Transport ATP Biosynthetic Process Phagosome Maturation Proton Transport Negative Regulation Of Transcription Factor Import Into Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lipid Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Male Germ Cell Proliferation Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Sensory Organ Boundary Specification Negative Regulation Of Small GTPase Mediated Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process ATP Hydrolysis Coupled Proton Transport Regulation Of MAPK Cascade Cellular Response To Stimulus Negative Regulation Of Protein Import Into Nucleus Small Molecule Metabolic Process Cellular Aromatic Compound Metabolic Process Monovalent Inorganic Cation Transport Purine Ribonucleoside Monophosphate Biosynthetic Process Biosynthetic Process RNA Biosynthetic Process Taste Bud Development ERBB2 Signaling Pathway Ganglion Mother Cell Fate Determination Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Protein Localization To Nucleus RNA Metabolic Process Iron Ion Transport Cellular Iron Ion Homeostasis Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		aava accelerates atpase consolidating deregulated eevd endogenously enough gankyrin hek hot hub integrating interfaces mb mda migratory mutagenesis networks oncogenic oncoprotein pdb polypharmacological proteasome reflecting rescue searching silenced spot	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		aava accelerates atpase consolidating deregulated eevd endogenously enough gankyrin hek hot hub integrating interfaces mb mda migratory mutagenesis networks oncogenic oncoprotein pdb polypharmacological proteasome reflecting rescue searching silenced spot	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?