CLIC1 and TPRN

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CLIC1	TPRN
Description		chloride intracellular channel 1	taperin
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Endoplasmic Reticulum Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Monoatomic Ion Channel Complex Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle	Nucleus Nucleoplasm Cytoplasm Microvillus Stereocilium Cell Projection Stereocilium Base
	Molecular Function	Chloride Channel Activity Protein Binding Oxidoreductase Activity Cadherin Binding	Actin Binding Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Phosphatase Binding Protein Phosphatase Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Monoatomic Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport	Sensory Perception Of Sound Auditory Receptor Cell Stereocilium Organization Stereocilium Maintenance
Pathways			Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		Copper Artenimol
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 27863252) Ulcerative colitis ( 28067908)	Obesity-related traits ( 23251661)
Interacting Genes		25 interacting genes: AKAP9 ALOX5AP ANXA1 ATP5PB ATP6V0A1 ATP6V0C CEBPA CFTR CPT1A IKBKG LSM1 MEOX2 MYOC NHSL2 NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TPRN TRAPPC2 ZNF184 ZNF302	9 interacting genes: CLIC1 CLIC2 CLIC4 CLIC5 EPS8 MYO15B PPP1CA PPP1CC WHRN
Entrez ID		1192	286262
HPRD ID		04188	12977
Ensembl ID		ENSG00000213719	ENSG00000176058
Uniprot IDs		O00299 Q53FB0 Q5SRT3	Q4KMQ1
PDB IDs		1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA 4JZQ 4K0G 4K0N 7F8R 7FBQ	6Y9Q
Enriched GO Terms of Interacting Partners?			Chloride Channel Complex Chloride Channel Activity Chloride Transmembrane Transport Chloride Transport Inorganic Anion Transmembrane Transport Monoatomic Ion Channel Complex Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Stereocilium PTW/PP1 Phosphatase Complex Stereocilium Bundle Stereocilium Tip Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Photoperiodism Entrainment Of Circadian Clock Oxidoreductase Activity Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Brush Border Glycogen Metabolic Process Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Monoatomic Ion Transport Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Stereocilia Ankle Link USH2 Complex Extracellular Exosome Plasma Membrane Transmembrane Transport Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Termination Of DNA-templated Transcription Dephosphorylation Positive Regulation Of Termination Of RNA Polymerase II Transcription Branching Morphogenesis Of An Epithelial Tube Circadian Rhythm Phosphoprotein Phosphatase Activity Growth Cone Glutamatergic Synapse Dendritic Spine Stereocilia Ankle Link Complex
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