CLIC1 and NUP62

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CLIC1	NUP62
Name		chloride intracellular channel 1	nucleoporin 62
Structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Endoplasmic Reticulum Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Monoatomic Ion Channel Complex Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle	Spindle Pole Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Centrosome Cytoskeleton Nuclear Membrane Nuclear Pore Central Transport Channel Mitotic Spindle Flemming Body Ribonucleoprotein Complex
	Molecular Function	Chloride Channel Activity Protein Binding Oxidoreductase Activity Cadherin Binding	Chromatin Binding Protein Binding Phospholipid Binding Structural Constituent Of Nuclear Pore Signaling Receptor Complex Adaptor Activity Hsp70 Protein Binding SH2 Domain Binding Ubiquitin Binding PTB Domain Binding Hsp90 Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Monoatomic Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Mitotic Metaphase Chromosome Alignment Centrosome Cycle Mitotic Centrosome Separation Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Protein Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of Centriole Replication MRNA Transport Regulation Of Mitotic Spindle Organization Cellular Senescence Centriole Assembly Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome
Pathways		None	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Copper Artenimol	None
GWAS		Adult body size ( 32376654 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Inflammatory bowel disease ( 28067908 ) Mean platelet volume ( 27863252 ) Ulcerative colitis ( 28067908 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: DNAJC19 PCSK5	6 novel interactors: CYTH2 NAPSA NOSIP ZNF432 ZNF473 ZNF91
Interacting Genes		25 interacting genes: AKAP9 ALOX5AP ANXA1 ATP5PB ATP6V0A1 ATP6V0C CEBPA CFTR CPT1A IKBKG LSM1 MEOX2 MYOC NHSL2 NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TPRN TRAPPC2 ZNF184 ZNF302	88 interacting genes: ABI2 ADAM15 AGR3 ARFIP2 ATF7IP2 ATXN7 BFSP1 BLOC1S6 C14orf119 C1orf216 CAVIN3 CCDC121 CCDC146 CCDC150 CCHCR1 CENPU CEP57L1 CLIC1 CRCT1 DDX3X DGCR6 DPPA3 DRC12 DTNB DYNLT1 FABP3 GOPC GORASP2 GTF2E2 HAUS1 HGS HSF2 HSF4 IDH1 IFT20 IFT25 IK IKBIP IPO5 ISCU KANSL1 KIFC3 KLHL32 KPNA1 KPNA2 KPNB1 KRT1 KRT20 KRT3 KRT6A KRT6B KRT75 LMO2 LNX1 MUC1 MXD3 MYO15B NUP153 NUP54 NUP58 NUP98 NUTF2 NXF1 NXF2 OGT OIP5 OTUD6A PBX2 PELI2 PIN1 PTMA RANBP2 SMARCA2 SMARCE1 SNAPC5 SP1 SSC5D SUOX THAP1 TLE4 TRAF3 TRIML2 TXLNA TXN USHBP1 WASHC3 XPO1 XPO6
Entrez ID		1192	23636
HPRD ID		04188	05782
Ensembl ID		ENSG00000213719	ENSG00000213024
Uniprot IDs		O00299 Q53FB0 Q5SRT3	P37198
PDB IDs		1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA 4JZQ 4K0G 4K0N 7F8R 7FBQ	5IJN 5IJO 7PER 7R5J 7R5K
GO Terms Enriched among Interactors		None	Nuclear Transport Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Nuclear Pore NLS-bearing Protein Import Into Nucleus RNA Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Export MRNA Transport Intracellular Transport Nuclear Import Signal Receptor Activity Protein Localization To Nucleus Protein Transport Establishment Of Protein Localization Structural Constituent Of Nuclear Pore Intermediate Filament Organization Nuclear Membrane Nucleobase-containing Compound Transport Nuclear Inclusion Body Protein Binding Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intracellular Protein Transport Cellular Localization Protein Localization To Organelle Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle Supramolecular Fiber Organization Nuclear Envelope Intracellular Protein Localization Intracellular Transport Of Virus Keratin Filament Host Cell NLS-dependent Protein Nuclear Import Complex Cytoskeleton Organization Small GTPase Binding Intermediate Filament Protein Export From Nucleus Keratinization Nuclear Pore Nuclear Basket Regulation Of Nucleocytoplasmic Transport Nuclear Pore Organization Identical Protein Binding RNA Export From Nucleus Nucleus Organization Organelle Organization Ribosomal Protein Import Into Nucleus Viral Penetration Into Host Nucleus