CLIC1 and CPT1A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CLIC1	CPT1A
Gene Name		chloride intracellular channel 1	carnitine palmitoyltransferase 1A (liver)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding	Carnitine O-palmitoyltransferase Activity Identical Protein Binding
	Biological Process	Chloride Transport Signal Transduction Regulation Of Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport	Long-chain Fatty Acid Metabolic Process Glucose Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Circadian Rhythm Carnitine Metabolic Process Response To Organic Cyclic Compound Epithelial Cell Differentiation Positive Regulation Of Fatty Acid Beta-oxidation Response To Drug Eating Behavior Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Fatty Acid
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Signaling by Retinoic Acid Import of palmitoyl-CoA into the mitochondrial matrix Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) RORA activates circadian gene expression
Drugs			L-Carnitine Perhexiline
Diseases
GWAS			Lipid metabolism phenotypes ( 22286219) Obesity-related traits ( 23251661)
Protein-Protein Interactions		19 interactors: AKAP9 ALOX5AP ATP5F1 ATP6V0A1 ATP6V0C CPT1A IKBKG LSM1 MYOC NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TRAPPC2 ZNF184 ZNF302	7 interactors: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1
Entrez ID		1192	1374
HPRD ID		04188	02755
Ensembl ID		ENSG00000213719	ENSG00000110090
Uniprot IDs		O00299 Q5SRT3	B2RAQ8 P50416 Q8WZ48
PDB IDs		1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA	2LE3
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Cytoplasmic Sequestering Of Transcription Factor Gene Expression Cytoplasmic Sequestering Of Protein Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Localization Heterocycle Metabolic Process Transferrin Transport ATP Synthesis Coupled Proton Transport Hydrogen Ion Transmembrane Transport ATP Biosynthetic Process Phagosome Maturation Proton Transport Negative Regulation Of Transcription Factor Import Into Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lipid Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Male Germ Cell Proliferation Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Sensory Organ Boundary Specification Negative Regulation Of Small GTPase Mediated Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process ATP Hydrolysis Coupled Proton Transport Regulation Of MAPK Cascade Cellular Response To Stimulus Negative Regulation Of Protein Import Into Nucleus Small Molecule Metabolic Process Cellular Aromatic Compound Metabolic Process Monovalent Inorganic Cation Transport Purine Ribonucleoside Monophosphate Biosynthetic Process Biosynthetic Process RNA Biosynthetic Process Taste Bud Development ERBB2 Signaling Pathway Ganglion Mother Cell Fate Determination Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Protein Localization To Nucleus RNA Metabolic Process Iron Ion Transport Cellular Iron Ion Homeostasis Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus	Cellular Response To Glucose Starvation Regulation Of Mitochondrial Membrane Potential Response To Gamma Radiation Neural Nucleus Development Positive Regulation Of Endothelial Cell Proliferation Response To Nutrient Levels Response To Extracellular Stimulus Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Endothelial Cell Proliferation Renal System Process Negative Regulation Of Cellular PH Reduction Smooth Muscle Hypertrophy CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Glomerular Filtration By Angiotensin Regulation Of Body Fluid Levels Reactive Oxygen Species Metabolic Process Regulation Of Ion Transport Response To Stress Positive Regulation Of Cell Growth Metencephalon Development Cell Activation Response To External Stimulus Response To Wounding Cerebellum Structural Organization Response To Cytokine Cellular Response To Starvation Cellular Response To Organic Substance Response To Ionizing Radiation Positive Regulation Of Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Regulation Of Ion Homeostasis Innate Immune Response Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Neuron Maturation Regulation Of Renal Output By Angiotensin Positive Regulation Of Cell Proliferation Hindbrain Development Response To Toxic Substance Cellular Response To Nutrient Levels Response To Starvation Response To Organic Cyclic Compound Cochlear Nucleus Development Regulation Of Nitrogen Utilization Regulation Of Calcium Ion Transport Platelet Activation Intracellular Receptor Signaling Pathway Regulation Of Ossification Negative Regulation Of Apoptotic Process
Tagcloud ?		aava accelerates atpase consolidating deregulated eevd endogenously enough gankyrin hek hot hub integrating interfaces mb mda migratory mutagenesis networks oncogenic oncoprotein pdb polypharmacological proteasome reflecting rescue searching silenced spot	adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit
Tagcloud (Difference) ?		aava accelerates atpase consolidating deregulated eevd endogenously enough gankyrin hek hot hub integrating interfaces mb mda migratory mutagenesis networks oncogenic oncoprotein pdb polypharmacological proteasome reflecting rescue searching silenced spot	adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit
Tagcloud (Intersection) ?