AP3S1 and RUFY1

Number of citations of the paper that reports this interaction (PubMedID 23144738)
65

Data Source:
BioGRID (pull down)

		AP3S1	RUFY1
Description		adaptor related protein complex 3 subunit sigma 1	RUN and FYVE domain containing 1
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GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Membrane Membrane Coat AP-type Membrane Coat Adaptor Complex AP-3 Adaptor Complex Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Presynapse Axon Cytoplasm	Cytoplasm Endosome Cytosol Membrane Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Lipid Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity SH2 Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Anterograde Axonal Transport Insulin Receptor Signaling Pathway Protein Transport Synaptic Vesicle Coating Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Melanosome Assembly	Endocytosis Small GTPase-mediated Signal Transduction Protein Transport Regulation Of Endocytosis Endosomal Vesicle Fusion Early Endosome To Golgi Transport
Pathways		Golgi Associated Vesicle Biogenesis	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS			Daytime sleep phenotypes ( 27126917) Dental caries (decayed and filled deciduous teeth) ( 31533690) Eating disorders ( 22911880) Lung cancer ( 28604730) Monocyte percentage of white cells ( 32888494) TPE interval (resting) ( 32386560)
Interacting Genes		7 interacting genes: AP3B2 AP3D1 AP3S2 IRS1 RUFY1 SCARB2 SLC30A3	20 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX DYNC1LI1 EPHA3 GIT2 ITSN2 OAS1 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A SNCA TRIM23 TXNDC17 UTP25
Entrez ID		1176	80230
HPRD ID		03298	15282
Ensembl ID		ENSG00000177879	ENSG00000176783
Uniprot IDs		F5H459 Q92572	A8K7B1 Q96T51
PDB IDs		9C58 9C59 9C5B 9C5C	2YQM 2YW8
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Coating Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Synaptic Vesicle Recycling Membrane Coat Cellular Localization Vesicle Cargo Loading Synaptic Vesicle Transport Vesicle Coating Vacuolar Transport Anterograde Axonal Transport Vesicle Transport Along Microtubule Zinc Ion Import Into Lysosome Vesicle Cytoskeletal Trafficking Intracellular Transport Axon Cytoplasm Axonal Transport Establishment Of Protein Localization Vacuolar Transmembrane Transport Axo-dendritic Transport Organelle Transport Along Microtubule Vesicle Organization Zinc Ion Import Into Organelle Establishment Of Localization In Cell Establishment Of Vesicle Localization Vesicle Localization Lysosomal Transport Melanosome Assembly Intracellular Membrane-bounded Organelle Golgi To Vacuole Transport Protein Transport Platelet Dense Granule Organization Transport Along Microtubule Intracellular Protein Transport Zinc Ion Transmembrane Transport Vesicle-mediated Transport Zinc Ion Transport Cytoskeleton-dependent Intracellular Transport Protein Targeting Microtubule-based Transport Melanosome Organization Pigment Granule Organization SH2 Domain Binding Establishment Of Organelle Localization Golgi Vesicle Transport Protein Targeting To Vacuole Protein Localization To Lysosome Regulation Of Lipid Catabolic Process Early Endosome	Synaptic Vesicle Recycling Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Synaptic Vesicle Transport Vesicle-mediated Transport In Synapse Anterograde Synaptic Vesicle Transport Synaptic Vesicle Coating GDP Binding Cytoplasmic Vesicle Membrane Vesicle Cargo Loading Early Endosome Protein Transport Establishment Of Vesicle Localization Anterograde Axonal Transport Vesicle Transport Along Microtubule Establishment Of Localization In Cell Vesicle Localization Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Intracellular Protein Localization Melanosome Assembly G Protein Activity Intracellular Protein Transport Axo-dendritic Transport Cellular Localization GTP Binding Platelet Dense Granule Organization Organelle Transport Along Microtubule Intracellular Transport Membrane Coat Post-Golgi Vesicle-mediated Transport Presynapse Vesicle Coating Organelle Localization Melanosome Organization Establishment Of Organelle Localization Pigment Granule Organization Terminal Bouton Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle Organization GTPase Activity Transport Along Microtubule Receptor-mediated Endocytosis Nucleotide Binding Secretory Granule Organization Microtubule-based Movement
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