AP3S1 and AP3S2

Number of citations of the paper that reports this interaction (PMID 9118953)
89

Data Source:
HPRD (two hybrid, in vivo)

		AP3S1	AP3S2
Gene Name		adaptor-related protein complex 3, sigma 1 subunit	adaptor-related protein complex 3, sigma 2 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus AP-type Membrane Coat Adaptor Complex AP-3 Adaptor Complex Transport Vesicle Cytoplasmic Vesicle Membrane	Golgi Apparatus AP-3 Adaptor Complex Cytoplasmic Vesicle Membrane
	Molecular Function	Transporter Activity Protein Binding Protein Transporter Activity	Protein Transporter Activity
	Biological Process	Intracellular Protein Transport Anterograde Axon Cargo Transport Insulin Receptor Signaling Pathway Anterograde Synaptic Vesicle Transport	Intracellular Protein Transport Anterograde Axon Cargo Transport Anterograde Synaptic Vesicle Transport
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Type 2 diabetes ( 21874001)
Protein-Protein Interactions		7 interactors: AP3B2 AP3D1 AP3S2 IRS1 RUFY1 SCARB2 SLC30A3	6 interactors: AP3B1 AP3D1 AP3S1 ARF1 ARF6 E2F4
Entrez ID		1176	10239
HPRD ID		03298	03880
Ensembl ID			ENSG00000157823
Uniprot IDs		Q92572	P59780
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterograde Synaptic Vesicle Transport Anterograde Axon Cargo Transport Axon Cargo Transport Regulation Of Sequestering Of Zinc Ion Protein Localization Synaptic Vesicle Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Establishment Of Vesicle Localization Vesicle Localization Intracellular Protein Transport Microtubule-based Movement Establishment Of Organelle Localization Organelle Localization Cellular Localization Protein Localization To Organelle Vesicle-mediated Transport Transport Synaptic Transmission Intracellular Transport Synaptic Vesicle Membrane Organization Regulation Of Ion Homeostasis Microtubule-based Process Eye Pigment Biosynthetic Process Establishment Of Localization In Cell Cell-cell Signaling Positive Regulation Of NK T Cell Differentiation Eye Pigmentation Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Endosome To Melanosome Transport Pigment Granule Maturation Cellular Pigment Accumulation Positive Regulation Of Fatty Acid Beta-oxidation Protein Targeting To Lysosome Positive Regulation Of Glycogen Biosynthetic Process Protein Localization To Lysosome Positive Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus Melanosome Organization Protein Targeting To Vacuole JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Pigment Granule Organization Phosphatidylinositol 3-kinase Signaling Movement Of Cell Or Subcellular Component	Anterograde Synaptic Vesicle Transport Anterograde Axon Cargo Transport Establishment Of Vesicle Localization Vesicle Localization Axon Cargo Transport Establishment Of Organelle Localization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Organelle Localization Synaptic Vesicle Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Melanosome Organization Pigment Granule Organization Vesicle Organization Microtubule-based Process Protein Localization Antigen Processing And Presentation Microtubule-based Movement Positive Regulation Of Alpha-beta T Cell Differentiation Cellular Localization Cellular Pigmentation Cellular Protein Localization Signaling Positive Regulation Of T Cell Differentiation Protein Localization To Organelle Cell Communication Movement Of Cell Or Subcellular Component Organelle Organization Intracellular Transport Positive Regulation Of Lymphocyte Differentiation Synaptic Transmission Pigmentation Regulation Of T Cell Differentiation Synaptic Vesicle Membrane Organization Regulation Of Lymphocyte Differentiation Establishment Of Localization In Cell Regulation Of Endocytosis Eye Pigment Biosynthetic Process Cell-cell Signaling Intracellular Protein Transport Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Sequestering Of Zinc Ion Multi-ciliated Epithelial Cell Differentiation Positive Regulation Of Cell-cell Adhesion Eye Pigmentation
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