ARAP1 and INPP5D

Number of citations of the paper that reports this interaction (PMID 21275903)
4

Data Source:
BioGRID (two hybrid)

		ARAP1	INPP5D
Gene Name		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	inositol polyphosphate-5-phosphatase, 145kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane	Cytosol Membrane
	Molecular Function	Rho GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding Type 1 Angiotensin Receptor Binding	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Positive Regulation Of Receptor Recycling Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Regulation Of ARF GTPase Activity Positive Regulation Of Cdc42 GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System
Drugs
Diseases
GWAS		Fasting glucose-related traits (interaction with BMI) ( 22581228) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963)	Crohn's disease ( 22412388 23128233)
Protein-Protein Interactions		13 interactors: APP ARIH2 ARPC3 FGFR3 INPP5D KCTD12 PSD3 SH3KBP1 TAB1 TES TP53BP1 WAPAL XRCC6	40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17
Entrez ID		116985	3635
HPRD ID		09440	09033
Ensembl ID		ENSG00000186635	ENSG00000168918
Uniprot IDs		E7EU13 Q96P48	Q92835
PDB IDs			2YSX
Enriched GO Terms of Interacting Partners?		Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Immune System Process Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Developmental Growth Defense Response Regulation Of Signaling Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Generation Of Neurons Response To Stress Developmental Cell Growth Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Sister Chromatid Cohesion Synaptic Growth At Neuromuscular Junction Multicellular Organismal Development Neurogenesis Apoptotic Process Regulation Of Chromosome Condensation Cellular Hyperosmotic Salinity Response Collateral Sprouting In Absence Of Injury Programmed Cell Death Regulation Of Cellular Process Cell Death Death Regulation Of Cell Cycle Process Growth Regulation Of Cohesin Localization To Chromatin Neuron Differentiation Axonogenesis Collateral Sprouting Axon Midline Choice Point Recognition Developmental Growth Involved In Morphogenesis Double-strand Break Repair Cell Growth System Development Developmental Process Alveolar Secondary Septum Development Negative Regulation Of Interleukin-6 Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To X-ray Axon Development Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide
Tagcloud ?		abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?