ARAP1 and TP53BP1

Number of citations of the paper that reports this interaction (PMID 21275903)
4

Data Source:
BioGRID (two hybrid)

		ARAP1	TP53BP1
Gene Name		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	tumor protein p53 binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane	Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm
	Molecular Function	Rho GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding Type 1 Angiotensin Receptor Binding	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Cofactor Activity P53 Binding Damaged DNA Binding Protein Binding Methylated Histone Binding Telomeric DNA Binding
	Biological Process	Positive Regulation Of Receptor Recycling Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Regulation Of ARF GTPase Activity Positive Regulation Of Cdc42 GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS		Fasting glucose-related traits (interaction with BMI) ( 22581228) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		13 interactors: APP ARIH2 ARPC3 FGFR3 INPP5D KCTD12 PSD3 SH3KBP1 TAB1 TES TP53BP1 WAPAL XRCC6	34 interactors: ARAP1 ATM BLM BRCA1 CCNB1 CDK1 CRB2 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AFX HIST1H4A HIST2H4A HIST4H4 IFI16 LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 PAXIP1 PCNT PLK1 RAD18 RELA SPAG9 TFDP1 TP53 USP28 VAC14
Entrez ID		116985	7158
HPRD ID		09440	05569
Ensembl ID		ENSG00000186635	ENSG00000067369
Uniprot IDs		E7EU13 Q96P48	F8VY86 Q12888
PDB IDs			1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 3LGF 3LGL 3LH0
Enriched GO Terms of Interacting Partners?		Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Immune System Process Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Developmental Growth Defense Response Regulation Of Signaling Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Generation Of Neurons Response To Stress Developmental Cell Growth Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Sister Chromatid Cohesion Synaptic Growth At Neuromuscular Junction Multicellular Organismal Development Neurogenesis Apoptotic Process Regulation Of Chromosome Condensation Cellular Hyperosmotic Salinity Response Collateral Sprouting In Absence Of Injury Programmed Cell Death Regulation Of Cellular Process Cell Death Death Regulation Of Cell Cycle Process Growth Regulation Of Cohesin Localization To Chromatin Neuron Differentiation Axonogenesis Collateral Sprouting Axon Midline Choice Point Recognition Developmental Growth Involved In Morphogenesis Double-strand Break Repair Cell Growth System Development Developmental Process Alveolar Secondary Septum Development Negative Regulation Of Interleukin-6 Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To X-ray Axon Development Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation	Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Process DNA Damage Checkpoint DNA Metabolic Process Response To Abiotic Stimulus Response To Radiation Mitotic Cell Cycle Process Cell Cycle Checkpoint DNA Repair Nucleobase-containing Compound Metabolic Process Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Response To Stress Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cell Death Telomere Maintenance Death Apoptotic Signaling Pathway DNA Recombination Intracellular Signal Transduction Regulation Of Metabolic Process G2 DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Phase Transition Histone Modification Cell Cycle Phase Transition Apoptotic Process DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Programmed Cell Death DNA Packaging Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise	abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Difference) ?		abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise	abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Intersection) ?