ARAP1 and KCTD12

Number of citations of the paper that reports this interaction (PMID 21275903)
4

Data Source:
BioGRID (two hybrid)

		ARAP1	KCTD12
Gene Name		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	potassium channel tetramerization domain containing 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane	Cell Junction Presynaptic Membrane Receptor Complex Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Rho GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding Type 1 Angiotensin Receptor Binding	Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Receptor Recycling Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Regulation Of ARF GTPase Activity Positive Regulation Of Cdc42 GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Homooligomerization
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Fasting glucose-related traits (interaction with BMI) ( 22581228) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		13 interactors: APP ARIH2 ARPC3 FGFR3 INPP5D KCTD12 PSD3 SH3KBP1 TAB1 TES TP53BP1 WAPAL XRCC6	2 interactors: ARAP1 GABBR2
Entrez ID		116985	115207
HPRD ID		09440	11060
Ensembl ID		ENSG00000186635	ENSG00000178695
Uniprot IDs		E7EU13 Q96P48	Q96CX2
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Immune System Process Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Developmental Growth Defense Response Regulation Of Signaling Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Generation Of Neurons Response To Stress Developmental Cell Growth Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Sister Chromatid Cohesion Synaptic Growth At Neuromuscular Junction Multicellular Organismal Development Neurogenesis Apoptotic Process Regulation Of Chromosome Condensation Cellular Hyperosmotic Salinity Response Collateral Sprouting In Absence Of Injury Programmed Cell Death Regulation Of Cellular Process Cell Death Death Regulation Of Cell Cycle Process Growth Regulation Of Cohesin Localization To Chromatin Neuron Differentiation Axonogenesis Collateral Sprouting Axon Midline Choice Point Recognition Developmental Growth Involved In Morphogenesis Double-strand Break Repair Cell Growth System Development Developmental Process Alveolar Secondary Septum Development Negative Regulation Of Interleukin-6 Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To X-ray Axon Development Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation	Actin Filament Reorganization Involved In Cell Cycle Actin Filament Reorganization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Receptor Recycling Positive Regulation Of Cdc42 GTPase Activity Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Receptor Recycling Regulation Of Cdc42 GTPase Activity Negative Regulation Of CAMP Biosynthetic Process Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of CAMP Metabolic Process Positive Regulation Of Filopodium Assembly Negative Regulation Of Nucleotide Metabolic Process Regulation Of Filopodium Assembly Regulation Of Adenylate Cyclase Activity Regulation Of Stress Fiber Assembly Regulation Of Cyclase Activity Actin Cytoskeleton Reorganization Regulation Of ARF GTPase Activity Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Regulation Of ARF Protein Signal Transduction Regulation Of Cell Projection Assembly Regulation Of Catalytic Activity Regulation Of Cell Shape Negative Regulation Of Cytoskeleton Organization
Tagcloud ?		abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise
Tagcloud (Difference) ?		abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise
Tagcloud (Intersection) ?