ARAP1 and ARPC3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARAP1	ARPC3
Gene Name		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	actin related protein 2/3 complex, subunit 3, 21kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane	Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Extracellular Vesicular Exosome
	Molecular Function	Rho GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding Type 1 Angiotensin Receptor Binding	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Positive Regulation Of Receptor Recycling Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Regulation Of ARF GTPase Activity Positive Regulation Of Cdc42 GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly	Movement Of Cell Or Subcellular Component Axon Guidance Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway
Pathways		Rho GTPase cycle Signaling by Rho GTPases	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Fasting glucose-related traits (interaction with BMI) ( 22581228) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		13 interactors: APP ARIH2 ARPC3 FGFR3 INPP5D KCTD12 PSD3 SH3KBP1 TAB1 TES TP53BP1 WAPAL XRCC6	20 interactors: ACTR3 ARAP1 ARPC4 BAG6 CDKN2B CETP EFTUD2 GOLGA2 HOXA3 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 PRMT1 RPS4X THNSL2 WAS WASF2 WASL
Entrez ID		116985	10094
HPRD ID		09440	09175
Ensembl ID		ENSG00000186635	ENSG00000111229
Uniprot IDs		E7EU13 Q96P48	O15145
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Immune System Process Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Signal Transduction Fc Receptor Signaling Pathway Developmental Growth Defense Response Regulation Of Signaling Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Generation Of Neurons Response To Stress Developmental Cell Growth Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Sister Chromatid Cohesion Synaptic Growth At Neuromuscular Junction Multicellular Organismal Development Neurogenesis Apoptotic Process Regulation Of Chromosome Condensation Cellular Hyperosmotic Salinity Response Collateral Sprouting In Absence Of Injury Programmed Cell Death Regulation Of Cellular Process Cell Death Death Regulation Of Cell Cycle Process Growth Regulation Of Cohesin Localization To Chromatin Neuron Differentiation Axonogenesis Collateral Sprouting Axon Midline Choice Point Recognition Developmental Growth Involved In Morphogenesis Double-strand Break Repair Cell Growth System Development Developmental Process Alveolar Secondary Septum Development Negative Regulation Of Interleukin-6 Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To X-ray Axon Development Epidermal Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Phagocytosis Regulation Of Cytoskeleton Organization Fc Receptor Signaling Pathway Regulation Of Cell Projection Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Regulation Of Filopodium Assembly Actin Filament-based Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Actin Filament-based Movement Positive Regulation Of Cytoskeleton Organization Immune System Process Immune Response-regulating Signaling Pathway Innate Immune Response Negative Regulation Of Stress Fiber Assembly Actin Polymerization Or Depolymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Lamellipodium Assembly Defense Response Cell Cycle Regulation Of Organelle Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Megakaryocyte Differentiation Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Cytoskeleton Organization Positive Regulation Of Organelle Organization Immune Response Arp2/3 Complex-mediated Actin Nucleation Regulation Of Immune System Process Regulation Of Immune Response Actin Filament Polymerization Regulation Of Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process
Tagcloud ?		abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise	aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream
Tagcloud (Difference) ?		abl1 annotates bcr casl centd2 compensate crk crki crkii directionality dok dok1 dok2 gab2 gtpase gtpases hef1 layered lrrk1 lrrk2 modular nedd9 paralog pleiotropic pragmin rhoa sgk223 shc1 wise	aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream
Tagcloud (Intersection) ?