ARAP1 and ARIH2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARAP1	ARIH2
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	ariadne RBR E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Ruffle Podosome Nucleoplasm Cytoplasm Endosome Early Endosome Multivesicular Body Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Cell Projection Anchoring Junction	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Receptor Internalization Actin Filament Organization Signal Transduction Regulation Of Cell Shape Regulation Of Endocytosis Regulation Of Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Photoreceptor Cell Maintenance Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Developmental Cell Growth Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 25673413 28892062) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Fasting blood glucose ( 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 30297969 30718926 30054458 26961502 29358691 32499647 28869590 26818947 24509480 22885922) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)
Interacting Genes		15 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 FILNC1 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6	57 interacting genes: APOBEC3C APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST DSCAM EEF1A1 EEF1G EIF4E2 EML4 ENSA IL4R KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN RBX1 REL RHEB RNF7 RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 USP2-AS1 UTP14A WDR91
Entrez ID		116985	10425
HPRD ID		09440	09286
Ensembl ID		ENSG00000186635	ENSG00000177479
Uniprot IDs		E7EU13 Q96P48	O95376 Q53ET9 Q6IBL8
PDB IDs		4X1V	7OD1 7ONI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Focal Adhesion Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Immune System Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Supramolecular Fiber Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Postsynapse Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Endocytosis Positive Regulation Of Lamellipodium Assembly GTP-dependent Protein Binding Phagocytosis, Engulfment Telomeric DNA Binding Hyperosmotic Response Response To X-ray Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Negative Regulation Of DNA Replication Intracellular Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Protein-containing Complex Cell Projection Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Innate Immune Response Regulation Of Lamellipodium Assembly Positive Regulation Of MAPK Cascade Protein Homooligomerization Neuron Projection Organization Intracellular Signaling Cassette Receptor Complex Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Protein Monoubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Cytosol Transferase Activity Macromolecule Metabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Metabolic Process Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Proteolysis TOR Signaling Catabolic Process Protein Neddylation ISG15-protein Conjugation DNA Cytosine Deamination TORC1 Signaling Nucleoplasm Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cytidine To Uridine Editing Cytidine Deaminase Activity DNA Deamination Negative Regulation Of Neuroblast Proliferation Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Neuroblast Proliferation Regulation Of Neural Precursor Cell Proliferation Regulation Of Post-translational Protein Modification Base Conversion Or Substitution Editing Negative Regulation Of Gene Expression Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination UBC13-MMS2 Complex Regulation Of Protein Metabolic Process Ubiquitin-like Protein Transferase Activity Ubiquitin Ligase Complex
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