ARAP1 and WAPL

Number of citations of the paper that reports this interaction (PubMedID 21275903)
45

Data Source:
BioGRID (two hybrid)

		ARAP1	WAPL
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	WAPL cohesin release factor
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GO Annotations	Cellular Component	Ruffle Podosome Nucleoplasm Cytoplasm Endosome Early Endosome Multivesicular Body Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Cell Projection Anchoring Junction	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Intercellular Bridge Mitotic Spindle
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding	Protein Binding ATP-dependent Protein-DNA Unloader Activity
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Receptor Internalization Actin Filament Organization Signal Transduction Regulation Of Cell Shape Regulation Of Endocytosis Regulation Of Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Photoreceptor Cell Maintenance Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly	Mitotic Sister Chromatid Segregation Negative Regulation Of DNA Replication Negative Regulation Of Chromatin Binding Negative Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin
Pathways		PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs
Diseases
GWAS		Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 25673413 28892062) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Fasting blood glucose ( 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 30297969 30718926 30054458 26961502 29358691 32499647 28869590 26818947 24509480 22885922) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)	Parental longevity (father's age at death) ( 31484785)
Interacting Genes		15 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 FILNC1 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6	7 interacting genes: ARAP1 BTG3 CDCA5 MTNR1A RAD21 SUMO2 XRN1
Entrez ID		116985	23063
HPRD ID		09440	11072
Ensembl ID		ENSG00000186635	ENSG00000062650
Uniprot IDs		E7EU13 Q96P48	A8K273 B2RTX8 Q7Z5K2
PDB IDs		4X1V	4K6J 5HDT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Focal Adhesion Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Immune System Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Supramolecular Fiber Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Postsynapse Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Endocytosis Positive Regulation Of Lamellipodium Assembly GTP-dependent Protein Binding Phagocytosis, Engulfment Telomeric DNA Binding Hyperosmotic Response Response To X-ray Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Negative Regulation Of DNA Replication Intracellular Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Protein-containing Complex Cell Projection Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Innate Immune Response Regulation Of Lamellipodium Assembly Positive Regulation Of MAPK Cascade Protein Homooligomerization Neuron Projection Organization Intracellular Signaling Cassette Receptor Complex Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling	Sister Chromatid Cohesion Negative Regulation Of Chromosome Organization Cellular Response To Puromycin Cellular Response To Cycloheximide
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