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ARAP1
Gene Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Apparatus
Trans-Golgi Network
Cytosol
Plasma Membrane
Cytoplasmic Vesicle
Golgi Cisterna Membrane
Molecular Function
Rho GTPase Activator Activity
Protein Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
ARF GTPase Activator Activity
Zinc Ion Binding
Type 1 Angiotensin Receptor Binding
Biological Process
Positive Regulation Of Receptor Recycling
Small GTPase Mediated Signal Transduction
Regulation Of Cell Shape
Actin Filament Reorganization Involved In Cell Cycle
Regulation Of ARF GTPase Activity
Positive Regulation Of Cdc42 GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cellular Component Movement
Positive Regulation Of Filopodium Assembly
Negative Regulation Of Stress Fiber Assembly
Pathways
Rho GTPase cycle
Signaling by Rho GTPases
Drugs
Diseases
GWAS
Fasting glucose-related traits (interaction with BMI) (
22581228
)
Proinsulin levels (
21873549
)
Rheumatoid arthritis (
22446963
)
Protein-protein Interactions
13 interactors:
APP
ARIH2
ARPC3
FGFR3
INPP5D
KCTD12
PSD3
SH3KBP1
TAB1
TES
TP53BP1
WAPAL
XRCC6
Entrez ID
116985
HPRD ID
09440
Ensembl ID
ENSG00000186635
Uniprot IDs
E7EU13
Q96P48
PDB IDs
Enriched GO Terms of Interacting Partners
?
Immune Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Innate Immune Response
Immune System Process
Immune Response-regulating Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Signal Transduction
Fc Receptor Signaling Pathway
Developmental Growth
Defense Response
Regulation Of Signaling
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Regulation Of Immune Response
Generation Of Neurons
Response To Stress
Developmental Cell Growth
Enzyme Linked Receptor Protein Signaling Pathway
Negative Regulation Of Sister Chromatid Cohesion
Synaptic Growth At Neuromuscular Junction
Multicellular Organismal Development
Neurogenesis
Apoptotic Process
Regulation Of Chromosome Condensation
Cellular Hyperosmotic Salinity Response
Collateral Sprouting In Absence Of Injury
Programmed Cell Death
Regulation Of Cellular Process
Cell Death
Death
Regulation Of Cell Cycle Process
Growth
Regulation Of Cohesin Localization To Chromatin
Neuron Differentiation
Axonogenesis
Collateral Sprouting
Axon Midline Choice Point Recognition
Developmental Growth Involved In Morphogenesis
Double-strand Break Repair
Cell Growth
System Development
Developmental Process
Alveolar Secondary Septum Development
Negative Regulation Of Interleukin-6 Biosynthetic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Cellular Response To X-ray
Axon Development
Epidermal Growth Factor Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud
?
abl1
annotates
bcr
casl
centd2
compensate
crk
crki
crkii
directionality
dok
dok1
dok2
gab2
gtpase
gtpases
hef1
layered
lrrk1
lrrk2
modular
nedd9
paralog
pleiotropic
pragmin
rhoa
sgk223
shc1
wise