TRIM9 and VASP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, proximity labelling technology)
HPRD (two hybrid)

		TRIM9	VASP
Description		tripartite motif containing 9	vasodilator stimulated phosphoprotein
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Synaptic Vesicle Dendrite Cytoplasmic Vesicle Cell Projection Synapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Cell Projection Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Psychosis (atypical) ( 24132900) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Urate levels (BMI interaction) ( 25811787)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		33 interacting genes: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL FAM124B FAM90A1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID NRIP1 NTAQ1 PCGF3 RNF166 RPL4P5 SHANK3 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 UTP25 VASP	49 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 AEBP1 APBB1 APBB1IP CDC42 CEBPA DMRTB1 DNMBP ENAH ERMAP FAF2 FAT1 FRS3 FYB1 GSN IQGAP1 LPP MAGED1 MRPL43 NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SHROOM3 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XIRP2 XPO6 ZYX
Entrez ID		114088	7408
HPRD ID		05947	03415
Ensembl ID		ENSG00000100505	ENSG00000125753
Uniprot IDs		A0A804HIL7 Q9C026	A0A024R0V4 P50552
PDB IDs		2DB8 7B2S	1EGX 1USD 1USE 2PAV 2PBD 3CHW 8GAT 8GAU
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Destabilization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Anterograde Synaptic Vesicle Transport Protein Modification Process Regulation Of Protein Stability SUMO Transferase Activity Positive Regulation Of Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Synaptic Vesicle Transport Establishment Of Vesicle Localization SH3 Domain Binding Vesicle Localization Vesicle Transport Along Microtubule Anterograde Axonal Transport Ubiquitin-protein Transferase Activity Protein Sumoylation Profilin Binding Vesicle Cytoskeletal Trafficking Protein Metabolic Process Zinc Ion Binding Axon Cytoplasm Axonal Transport Circadian Regulation Of Gene Expression Positive Regulation Of Autophagy BLOC-1 Complex Negative Regulation Of Cell Projection Organization Protein K63-linked Ubiquitination Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Axo-dendritic Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Organelle Transport Along Microtubule Positive Regulation Of Proteolysis Regulation Of Viral Transcription Regulation Of Biological Quality Microtubule-based Transport Platelet Dense Granule Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Neuron Projection Development Rhythmic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Response To Formaldehyde	Actin Filament Organization Focal Adhesion Lamellipodium Supramolecular Fiber Organization Actin Filament-based Process Anchoring Junction Actin Cytoskeleton Organization Cytoskeleton Filopodium Actin Cytoskeleton Cytoplasm Actin Binding Actin Polymerization Or Depolymerization Regulation Of Actin Filament Organization Cytoskeleton Organization Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cytosol Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin-based Cell Projection Actin Filament Binding Cellular Response To Type II Interferon SCAR Complex Phagocytic Vesicle Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Actin Filament Stress Fiber Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Stress Fiber Assembly Organelle Organization Response To Type II Interferon Cell Projection Morphogenesis Regulation Of Lamellipodium Organization Regulation Of Cytoskeleton Organization Adherens Junction SH3 Domain Binding Cortical Actin Cytoskeleton Modification Of Postsynaptic Structure Negative Regulation Of Cellular Component Organization Cell Leading Edge Modification Of Synaptic Structure Cell Projection Organization Cell Junction Organization Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Ruffle Assembly Actin Filament Polymerization
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