TRIM9 and MUL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TRIM9	MUL1
Description		tripartite motif containing 9	mitochondrial E3 ubiquitin protein ligase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Synaptic Vesicle Dendrite Cytoplasmic Vesicle Cell Projection Synapse	Mitochondrion Mitochondrial Outer Membrane Peroxisome Membrane Axon Neuronal Cell Body
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Mitochondrial Fission Apoptotic Process Positive Regulation Of Metabolic Process Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Positive Regulation Of Developmental Process Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Type 2 Mitophagy
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Psychosis (atypical) ( 24132900) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Urate levels (BMI interaction) ( 25811787)	Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		33 interacting genes: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL FAM124B FAM90A1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID NRIP1 NTAQ1 PCGF3 RNF166 RPL4P5 SHANK3 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 UTP25 VASP	34 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 KRTAP10-8 MAP3K7 RANGAP1 REEP2 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W UBXN7 ULK1
Entrez ID		114088	79594
HPRD ID		05947	07799
Ensembl ID		ENSG00000100505	ENSG00000090432
Uniprot IDs		A0A804HIL7 Q9C026	Q969V5
PDB IDs		2DB8 7B2S	6K2K 6M2C 6M2D
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Destabilization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Anterograde Synaptic Vesicle Transport Protein Modification Process Regulation Of Protein Stability SUMO Transferase Activity Positive Regulation Of Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Synaptic Vesicle Transport Establishment Of Vesicle Localization SH3 Domain Binding Vesicle Localization Vesicle Transport Along Microtubule Anterograde Axonal Transport Ubiquitin-protein Transferase Activity Protein Sumoylation Profilin Binding Vesicle Cytoskeletal Trafficking Protein Metabolic Process Zinc Ion Binding Axon Cytoplasm Axonal Transport Circadian Regulation Of Gene Expression Positive Regulation Of Autophagy BLOC-1 Complex Negative Regulation Of Cell Projection Organization Protein K63-linked Ubiquitination Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Axo-dendritic Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Organelle Transport Along Microtubule Positive Regulation Of Proteolysis Regulation Of Viral Transcription Regulation Of Biological Quality Microtubule-based Transport Platelet Dense Granule Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Neuron Projection Development Rhythmic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Response To Formaldehyde	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Ubiquitin-protein Transferase Activity Proteolysis Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Nucleotide Binding ATP Binding Protein K11-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Transferase Activity Proteasomal Protein Catabolic Process Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Regulation Of Macroautophagy ISG15-protein Conjugation Cellular Response To Interferon-beta DNA Damage Response Protein K63-linked Ubiquitination Response To Interferon-beta Cellular Response To Stress Cytosol Response To Stress DNA Repair Positive Regulation Of Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of Autophagy Nucleoplasm TORC1 Signaling Negative Regulation Of TORC1 Signaling Apoptotic Mitochondrial Changes DNA Metabolic Process Cellular Response To Nutrient Levels UBC13-MMS2 Complex Protein K6-linked Ubiquitination CGAS/STING Signaling Pathway TOR Signaling Ubiquitin Conjugating Enzyme Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?