TRIM9 and NCF1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)

		TRIM9	NCF1
Gene Name		tripartite motif containing 9	neutrophil cytosolic factor 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Synaptic Vesicle Cell Junction Dendrite	Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	SNARE Binding Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Protein Homodimerization Activity	Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Synaptic Vesicle Exocytosis Protein Ubiquitination Negative Regulation Of SNARE Complex Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Calcium Ion-dependent Exocytosis	Response To Yeast Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Apoptotic Process Inflammatory Response Cellular Defense Response Cell Proliferation Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Negative Regulation Of Smooth Muscle Contraction Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Interaction With Host Oxidation-reduction Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Phagosome Maturation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL EXOC1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID PCGF3 RNF166 RPL4P5 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 VASP	23 interactors: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF4 NOXA1 PRKCA PRKCB PRKCD PRKCZ PRKDC SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		114088	653361
HPRD ID		05947
Ensembl ID		ENSG00000100505	ENSG00000158517
Uniprot IDs		Q9C026	P14598
PDB IDs		2DB8	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Organelle Organization Regulation Of Protein Stability Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Viral Transcription Protein Complex Assembly Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Release From Host Cell Regulation Of Circadian Rhythm Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization Cellular Macromolecule Catabolic Process Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Viral Transcription Positive Regulation Of Proteolysis Regulation Of Viral Release From Host Cell Cellular Protein Catabolic Process Positive Regulation Of Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Protein Destabilization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Catabolic Process Anterograde Axon Cargo Transport Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Viral Process Mitotic Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Positive Regulation Of Organelle Organization Circadian Rhythm Regulation Of Actin Filament Polymerization Organelle Localization Mitotic Cell Cycle Cellular Response To UV-C Cellular Response To Vitamin B1 Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Cytoskeleton Organization Establishment Of Vesicle Localization	Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Histone H3-T6 Phosphorylation Platelet Activation Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Peptidyl-threonine Phosphorylation Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Immune Response Apoptotic Signaling Pathway Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Phospholipase Activity Cell Death Regulation Of Protein Phosphorylation Death Blood Coagulation Regulation Of Cellular Protein Metabolic Process Hemostasis Cell Surface Receptor Signaling Pathway Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Organelle Organization Mitotic Cell Cycle Positive Regulation Of Lipase Activity Response To Interleukin-1 Innate Immune Response Regulation Of Glucose Transport Regulation Of Platelet Aggregation Regulation Of Protein Metabolic Process Muscle System Process Negative Regulation Of Glucose Transport Signaling Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Protein Phosphorylation Peptidyl-serine Phosphorylation
Tagcloud ?		alteration alterations arf cadps2 frequently gain genomic hot ink4a instability mutants mutation mutations obvious p16 p53 piwil4 point prepared reason restraining resulting saos specificity spot suppresses suppressor transcriptional tumors	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Difference) ?		alteration alterations arf cadps2 frequently gain genomic hot ink4a instability mutants mutation mutations obvious p16 p53 piwil4 point prepared reason restraining resulting saos specificity spot suppresses suppressor transcriptional tumors	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Intersection) ?