TRIM9 and FAM124B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM9	FAM124B
Description		tripartite motif containing 9	family with sequence similarity 124 member B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Synaptic Vesicle Dendrite Cytoplasmic Vesicle Cell Projection Synapse	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Psychosis (atypical) ( 24132900) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Urate levels (BMI interaction) ( 25811787)	Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Familial squamous cell lung carcinoma ( 29924316)
Interacting Genes		33 interacting genes: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL FAM124B FAM90A1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID NRIP1 NTAQ1 PCGF3 RNF166 RPL4P5 SHANK3 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 UTP25 VASP	67 interacting genes: ABI1 ABI3 ADAMTSL4 BIRC7 BLZF1 CARD9 CCDC85B CYSRT1 DRC12 EFEMP2 EFHC2 ESM1 GIGYF1 GKAP1 GOLGA2 GPRASP2 GPRASP3 GRB7 HSF2BP IHO1 IKZF3 ISCA2 KCTD6 KCTD9 KIAA1958 KRT19 KRT31 KRT40 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 KRTAP9-3 LHX3 LZTS2 MBD3L1 MDFI MIPOL1 MKRN3 MTUS2 MYF5 NADK NOTCH2NLA RBPMS RINT1 RSPH3 SEPTIN14 SH2B2 SP7 SSX2IP TCF4 TLE5 TRAF2 TRIM37 TRIM42 TRIM54 TRIM8 TRIM9 TRIP6 USHBP1 USP54 WDR83 ZBED1 ZNF69 ZNF774 ZRANB1
Entrez ID		114088	79843
HPRD ID		05947	08663
Ensembl ID		ENSG00000100505	ENSG00000124019
Uniprot IDs		A0A804HIL7 Q9C026	Q9H5Z6
PDB IDs		2DB8 7B2S
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Destabilization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Anterograde Synaptic Vesicle Transport Protein Modification Process Regulation Of Protein Stability SUMO Transferase Activity Positive Regulation Of Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Synaptic Vesicle Transport Establishment Of Vesicle Localization SH3 Domain Binding Vesicle Localization Vesicle Transport Along Microtubule Anterograde Axonal Transport Ubiquitin-protein Transferase Activity Protein Sumoylation Profilin Binding Vesicle Cytoskeletal Trafficking Protein Metabolic Process Zinc Ion Binding Axon Cytoplasm Axonal Transport Circadian Regulation Of Gene Expression Positive Regulation Of Autophagy BLOC-1 Complex Negative Regulation Of Cell Projection Organization Protein K63-linked Ubiquitination Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Axo-dendritic Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Organelle Transport Along Microtubule Positive Regulation Of Proteolysis Regulation Of Viral Transcription Regulation Of Biological Quality Microtubule-based Transport Platelet Dense Granule Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Neuron Projection Development Rhythmic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Response To Formaldehyde	Identical Protein Binding Keratin Filament Intermediate Filament Protein Binding Ubiquitin Protein Ligase Activity Signaling Adaptor Activity Post-translational Protein Modification Cytoskeleton Protein Modification By Small Protein Conjugation Protein Ubiquitination
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