TRIM9 and TRIM8

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		TRIM9	TRIM8
Gene Name		tripartite motif containing 9	tripartite motif containing 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Synaptic Vesicle Cell Junction Dendrite	Nucleoplasm Cytoplasm Cytosol PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	SNARE Binding Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Protein Homodimerization Activity	Zinc Ion Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Synaptic Vesicle Exocytosis Protein Ubiquitination Negative Regulation Of SNARE Complex Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Calcium Ion-dependent Exocytosis	Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Viral Release From Host Cell
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		28 interactors: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL EXOC1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID PCGF3 RNF166 RPL4P5 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 VASP	45 interactors: BRAP CBL CCNH ITSN1 MAP3K7 MKRN3 MSL2 OTUB2 PCGF5 RAD18 RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF181 RNF41 RNF7 SIAH1 SOCS1 TNFAIP3 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UHRF2 USP2 USP21 USP39 USP7 XIAP
Entrez ID		114088	81603
HPRD ID		05947	06934
Ensembl ID		ENSG00000100505	ENSG00000171206
Uniprot IDs		Q9C026	Q9BZR9
PDB IDs		2DB8
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Organelle Organization Regulation Of Protein Stability Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Viral Transcription Protein Complex Assembly Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Release From Host Cell Regulation Of Circadian Rhythm Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization Cellular Macromolecule Catabolic Process Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Viral Transcription Positive Regulation Of Proteolysis Regulation Of Viral Release From Host Cell Cellular Protein Catabolic Process Positive Regulation Of Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Protein Destabilization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Catabolic Process Anterograde Axon Cargo Transport Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Viral Process Mitotic Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Positive Regulation Of Organelle Organization Circadian Rhythm Regulation Of Actin Filament Polymerization Organelle Localization Mitotic Cell Cycle Cellular Response To UV-C Cellular Response To Vitamin B1 Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Cytoskeleton Organization Establishment Of Vesicle Localization	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Protein Deubiquitination Negative Regulation Of Type I Interferon Production Immune Response Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Protein Modification By Small Protein Removal Regulation Of Metabolic Process Negative Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K48-linked Deubiquitination Regulation Of Gene Expression Protein K63-linked Deubiquitination Cellular Process Regulation Of Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		alteration alterations arf cadps2 frequently gain genomic hot ink4a instability mutants mutation mutations obvious p16 p53 piwil4 point prepared reason restraining resulting saos specificity spot suppresses suppressor transcriptional tumors	aggressive ccrcc chemotherapeutic cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator p53 rcc re regulators renders restoring stabilizes suppress treating tumours way wild
Tagcloud (Difference) ?		alteration alterations arf cadps2 frequently gain genomic hot ink4a instability mutants mutation mutations obvious p16 piwil4 point prepared reason restraining resulting saos specificity spot suppresses suppressor transcriptional tumors	aggressive ccrcc chemotherapeutic cytotoxic defective deficit define dramatically enhancer impairing impairs inactivated inactivation link mdm2 mechanistic modulator rcc re regulators renders restoring stabilizes suppress treating tumours way wild
Tagcloud (Intersection) ?		p53