CBX3 and HIPK2

Number of citations of the paper that reports this interaction (PubMedID 25151962)
0

Data Source:
BioGRID (enzymatic study)

		CBX3	HIPK2
Description		chromobox 3	homeodomain interacting protein kinase 2
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus Chromatin Lock Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Nuclear Body PML Body Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Coregulator Binding Chromatin Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding	Nucleotide Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SMAD Binding Virion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Dexamethasone Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Respiratory System Process Protein Phosphorylation Apoptotic Process DNA Damage Response Transforming Growth Factor Beta Receptor Signaling Pathway Smoothened Signaling Pathway Adult Walking Behavior Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Anterior/posterior Pattern Specification Gene Expression Retina Layer Formation Peptidyl-serine Phosphorylation Neuron Differentiation Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway PML Body Organization Thyroid Gland Development Epigenetic Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Embryonic Camera-type Eye Morphogenesis Voluntary Musculoskeletal Movement Neuron Apoptotic Process Regulation Of Cell Cycle Embryonic Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye SMAD Protein Signal Transduction Lung Morphogenesis Iris Morphogenesis Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6	YAP1- and WWTR1 (TAZ)-stimulated gene expression SUMOylation of transcription cofactors Physiological factors Regulation of TP53 Activity through Phosphorylation RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MECP2 expression and activity
Drugs			Fostamatinib
Diseases
GWAS		Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systolic blood pressure ( 28135244)
Interacting Genes		42 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280D ZNF496	57 interacting genes: AATF ABL1 BTRC CBX3 CHMP4B CREBBP CUL1 CXCL1 DAXX DAZAP2 DDX39A DDX39B FBXW7 H2BC21 HMGA1 KAT2B MAP3K7 MBP MDM2 MECP2 MKNK1 MYB MYBL1 NKX2-1 NKX2-5 NKX3-1 NLK NTRK1 PARP1 PAX6 PML PTCH1 RANBP9 RUNX1 SENP1 SETX SIAH1 SIAH2 SIRT1 SKI SMAD1 SMAD2 SMAD3 SP100 SPOP STIP1 SUMO1 SUMO2 SUMO3 TP53 TP53INP1 TP63 TP73 TRADD UBE2I WSB1 ZBTB4
Entrez ID		11335	28996
HPRD ID		05130	06039
Ensembl ID		ENSG00000122565	ENSG00000064393
Uniprot IDs		A4D177 B8ZZ43 Q13185	Q9H2X6
PDB IDs		2L11 3DM1 3KUP 3TZD 5T1I 6HW2 8JZW	6P5S 7NCF
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process DNA Binding Heterochromatin Regulation Of Mitotic Cell Cycle Chromo Shadow Domain Binding Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Chromocenter Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Nuclear Division Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Nuclear Division Nuclear Body Regulation Of Cell Cycle Spindle Midzone MIS12/MIND Type Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinetochore Chromosome, Centromeric Region Regulation Of Cell Cycle Process Structural Constituent Of Chromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Protein-containing Complex Chromosome Passenger Complex Attachment Of Spindle Microtubules To Kinetochore Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleosome Assembly Negative Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process	Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process PML Body Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of Developmental Process Nuclear Body Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Apoptotic Process Rhythmic Process DNA Damage Response Negative Regulation Of Cell Differentiation Regulation Of Apoptotic Process Programmed Cell Death P53 Binding Cell Death Macromolecule Metabolic Process
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