CBX3 and ZNF280D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid, proximity labelling technology, affinity chromatography technology)

		CBX3	ZNF280D
Description		chromobox 3	zinc finger protein 280D
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus Chromatin Lock Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage	Nucleus
	Molecular Function	Transcription Coregulator Binding Chromatin Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Dexamethasone Stimulus	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body fat mass ( 28552196) Glaucoma (primary open-angle) ( 29891935) Hand grip strength ( 29691431) Intraocular pressure ( 29785010 30054594 31959993) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Triglyceride levels ( 32203549)
Interacting Genes		42 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280D ZNF496	3 interacting genes: BRCA1 CBX3 CBX5
Entrez ID		11335	54816
HPRD ID		05130	15448
Ensembl ID		ENSG00000122565	ENSG00000137871
Uniprot IDs		A4D177 B8ZZ43 Q13185	Q6N043
PDB IDs		2L11 3DM1 3KUP 3TZD 5T1I 6HW2 8JZW
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process DNA Binding Heterochromatin Regulation Of Mitotic Cell Cycle Chromo Shadow Domain Binding Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Chromocenter Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Nuclear Division Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Nuclear Division Nuclear Body Regulation Of Cell Cycle Spindle Midzone MIS12/MIND Type Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinetochore Chromosome, Centromeric Region Regulation Of Cell Cycle Process Structural Constituent Of Chromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Protein-containing Complex Chromosome Passenger Complex Attachment Of Spindle Microtubules To Kinetochore Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleosome Assembly Negative Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process	Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation Epigenetic Regulation Of Gene Expression Pericentric Heterochromatin Site Of DNA Damage Heterochromatin Chromatin Remodeling DNA Damage Response Chromatin Organization Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of Gene Expression Chromosome, Centromeric Region Chromosome, Telomeric Region Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Envelope Negative Regulation Of RNA Metabolic Process Chromatin Lock Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process BRCA1-B Complex Senescence-associated Heterochromatin Focus Cellular Response To Stress Cellular Response To Indole-3-methanol Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Response To Indole-3-methanol Identical Protein Binding Negative Regulation Of Centriole Replication BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Ribonucleoprotein Complex Enzyme Binding Negative Regulation Of Centrosome Duplication Negative Regulation Of Macromolecule Biosynthetic Process Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Negative Regulation Of Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome Chromatin Binding Chromocenter XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Histone Methyltransferase Binding Condensed Chromosome, Centromeric Region Histone H3K9me2/3 Reader Activity
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