CBX3 and CACNB4

Number of citations of the paper that reports this interaction (PubMedID 21220418)
39

Data Source:
BioGRID (pull down)

		CBX3	CACNB4
Description		chromobox 3	calcium voltage-gated channel auxiliary subunit beta 4
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus Chromatin Lock Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Nuclear Speck Monoatomic Ion Channel Complex Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Transcription Coregulator Binding Chromatin Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Dexamethasone Stimulus	Monoatomic Ion Transport Calcium Ion Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuromuscular Junction Development Adult Walking Behavior Negative Regulation Of Cell Population Proliferation Gamma-aminobutyric Acid Secretion Neuronal Action Potential Propagation Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential CAMP Metabolic Process Spleen Development Thymus Development Peyer's Patch Development T Cell Receptor Signaling Pathway Nervous System Process Detection Of Light Stimulus Involved In Visual Perception Muscle Cell Development Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Protein Localization To Nucleolus Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6	Presynaptic depolarization and calcium channel opening NCAM1 interactions
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Nicardipine Magnesium sulfate Verapamil Levomenthol Nitrendipine Miconazole Amiodarone Mibefradil Dronedarone Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		42 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280D ZNF496	13 interacting genes: CACNA1A CBX3 CCDC102B CTBP2 EFHC2 FASLG MAP1A MED31 PTN REM1 SNCA SYT1 TBL3
Entrez ID		11335	785
HPRD ID		05130	09057
Ensembl ID		ENSG00000122565	ENSG00000182389
Uniprot IDs		A4D177 B8ZZ43 Q13185	A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 E7DBM8 H0Y476 O00305
PDB IDs		2L11 3DM1 3KUP 3TZD 5T1I 6HW2 8JZW	2D46
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process DNA Binding Heterochromatin Regulation Of Mitotic Cell Cycle Chromo Shadow Domain Binding Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Chromocenter Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Nuclear Division Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Nuclear Division Nuclear Body Regulation Of Cell Cycle Spindle Midzone MIS12/MIND Type Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinetochore Chromosome, Centromeric Region Regulation Of Cell Cycle Process Structural Constituent Of Chromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Protein-containing Complex Chromosome Passenger Complex Attachment Of Spindle Microtubules To Kinetochore Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleosome Assembly Negative Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process	Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Vesicle Fusion Regulation Of Dopamine Secretion Syntaxin Binding Synapse Transcription Coregulator Binding Regulation Of Synaptic Plasticity Dendrite Development Tau Protein Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Vesicle Fusion Positive Regulation Of SNARE Complex Assembly Regulation Of Catecholamine Secretion Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Secretion Synaptic Vesicle Exocytosis Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Cell-cell Signaling Signaling Cell Communication Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Chemical Synaptic Transmission Retrograde Axonal Protein Transport Primary Dendrite Dendrite Regeneration SNARE Binding Regulation Of Norepinephrine Uptake Regulation Of Amine Transport Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Syntaxin-3 Binding Calcium Ion Transmembrane Import Into Cytosol Retinal Cell Programmed Cell Death Trans-synaptic Signaling Synaptic Signaling Neuronal Cell Body Dendritic Branch Dendritic Microtubule Ossification Involved In Bone Remodeling Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Transporter Regulator Activity Regulation Of Neurotransmitter Secretion Vesicle-mediated Transport In Synapse Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
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