CBX3 and HTR2C

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CBX3	HTR2C
Description		chromobox 3	5-hydroxytryptamine receptor 2C
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus Chromatin Lock Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage	Plasma Membrane Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex
	Molecular Function	Transcription Coregulator Binding Chromatin Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity
	Biological Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Dexamethasone Stimulus	Behavioral Fear Response Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Calcium-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6	Serotonin receptors G alpha (q) signalling events
Drugs			Tramadol Ziprasidone Methysergide Cabergoline Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Flupentixol Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Pimavanserin Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Nandrolone decanoate Captodiame Viloxazine Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
Diseases
GWAS		Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		42 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280D ZNF496	34 interacting genes: APBA1 ARLN ARRB2 ATP2B3 ATP6AP2 ATP6V0C CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SLC71A1 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1
Entrez ID		11335	3358
HPRD ID		05130	02429
Ensembl ID		ENSG00000122565	ENSG00000147246
Uniprot IDs		A4D177 B8ZZ43 Q13185	K9J958 P28335
PDB IDs		2L11 3DM1 3KUP 3TZD 5T1I 6HW2 8JZW	6BQG 6BQH 8DPF 8DPG 8DPH 8DPI 8ZMF
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process DNA Binding Heterochromatin Regulation Of Mitotic Cell Cycle Chromo Shadow Domain Binding Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Chromocenter Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Nuclear Division Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Nuclear Division Nuclear Body Regulation Of Cell Cycle Spindle Midzone MIS12/MIND Type Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinetochore Chromosome, Centromeric Region Regulation Of Cell Cycle Process Structural Constituent Of Chromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Protein-containing Complex Chromosome Passenger Complex Attachment Of Spindle Microtubules To Kinetochore Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleosome Assembly Negative Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process	Membrane Endoplasmic Reticulum Membrane Plasma Membrane Transmembrane Transport Cellular Homeostasis Intracellular Chemical Homeostasis Homeostatic Process Chemical Homeostasis Synapse Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Cation Transmembrane Transport Endoplasmic Reticulum PDZ Domain Binding Monoatomic Cation Transmembrane Transport Ubiquitin Protein Ligase Binding Monoatomic Cation Homeostasis Regulation Of Lysosomal Lumen PH Monoatomic Ion Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Ion Transport D1 Dopamine Receptor Binding Monoatomic Cation Transport Glutamatergic Synapse Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Regulation Of Membrane Potential Neuron Cellular Homeostasis Glutamate Secretion Endosomal Lumen Acidification G Protein-coupled Receptor Binding Dystrophin-associated Glycoprotein Complex Proton-transporting V-type ATPase Complex Synaptic Vesicle Lumen Acidification Regulation Of Intracellular PH Bounding Membrane Of Organelle Regulation Of Cellular PH Regulation Of System Process Metal Ion Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Regulation Of Biological Quality Metal Ion Transport Regulation Of PH Zinc Ion Transmembrane Transporter Activity Positive Regulation Of Macrophage Cytokine Production Postsynapse Lysosomal Lumen Acidification Anchoring Junction Zinc Ion Transmembrane Transport
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