CBX3 and MKI67

Number of citations of the paper that reports this interaction (PMID 12485163)
4

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		CBX3	MKI67
Gene Name		chromobox homolog 3	marker of proliferation Ki-67
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin Spindle Nuclear Pericentric Heterochromatin	Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleolus Cytoplasm Membrane
	Molecular Function	Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding	Protein Binding ATP Binding Protein C-terminus Binding Poly(A) RNA Binding
	Biological Process	Chromatin Remodeling Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Rhythmic Process	Meiotic Nuclear Division Cell Proliferation
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription
Drugs
Diseases
GWAS			Select biomarker traits ( 17903293)
Protein-Protein Interactions		32 interactors: ARL5A ATXN7L2 AURKA AURKB CACNB4 CBX1 CBX5 DNMT3B DSN1 H3F3A HIST1H1E HIST1H3A HIST1H4A HIST3H3 KLF11 L3MBTL1 L3MBTL2 LBR MGA MIS12 MKI67 NIPBL NSL1 PIM1 SP100 TAF4 TRIM24 TRIM28 VHL WHSC1L1 ZNF10 ZNF496	10 interactors: CBX3 CBX5 CDK1 HINFP KIAA0368 KIF15 NIFK PRKCB SMN1 TK1
Entrez ID		11335	4288
HPRD ID		05130	08902
Ensembl ID		ENSG00000122565	ENSG00000148773
Uniprot IDs		A4D177 B8ZZ43 Q13185	P46013
PDB IDs		2L11 3DM1 3KUP 3TZD	1R21 2AFF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromosome Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process DNA Methylation Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Organelle Organization DNA Modification Chromatin Silencing Mitotic Cell Cycle Chromatin Silencing At RDNA Mitotic Cell Cycle Process Protein-DNA Complex Assembly Mitotic Nuclear Division Negative Regulation Of Gene Expression, Epigenetic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Gene Expression Regulation Of Gene Expression, Epigenetic Protein Autophosphorylation Nucleobase-containing Compound Metabolic Process Spindle Stabilization Gene Silencing Chromosome Segregation Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleosome Assembly Nitrogen Compound Metabolic Process Chromatin Assembly Cellular Nitrogen Compound Metabolic Process Protein Complex Assembly Nucleosome Organization Cell Cycle Process Chromatin Assembly Or Disassembly DNA Replication-dependent Nucleosome Assembly Transcription, DNA-templated DNA Packaging	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Mitotic Nuclear Envelope Disassembly Mitotic Cell Cycle Process Histone Phosphorylation Response To Wounding Nuclear Envelope Disassembly Peptidyl-threonine Phosphorylation Mitotic Cell Cycle Nuclear Envelope Organization Pronuclear Fusion Fetal Process Involved In Parturition Blood Coagulation Cell Cycle Process Hemostasis Nucleobase-containing Compound Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Skeletal Muscle Cell Proliferation Histone H3-T6 Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleus Organization Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Body Fluid Levels Macromolecule Biosynthetic Process Cell Cycle Wound Healing Chromatin Modification DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Toxic Substance Response To Cortisol Thymidine Metabolic Process Chromatin Organization Regulation Of Schwann Cell Differentiation Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of B Cell Receptor Signaling Pathway Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Protein Localization To Kinetochore Cell Cycle Checkpoint Protein Localization To Chromosome, Centromeric Region Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Component Assembly
Tagcloud ?		1gamma actively assembled biogenesis deformed depleted dnmt3a h3k27 h3k9 heterochromatin hp1gamma linker npm1 nucleolar nucleoli nucleolus organization organized organizer perinucleolar rdna repetitive repressive ribosome silver striking tethering trimethylated u1242mg	analyze associations bax bcl2 birc5 bladder carcinogenesis ccnd1 ccne1 demonstrates egfr heterozygosity indices intron loh methylation methylscreen papillary polymerase positively reveal reverse suppressor technology transduction tumorigenesis urothelial vegf wwox
Tagcloud (Difference) ?		1gamma actively assembled biogenesis deformed depleted dnmt3a h3k27 h3k9 heterochromatin hp1gamma linker npm1 nucleolar nucleoli nucleolus organization organized organizer perinucleolar rdna repetitive repressive ribosome silver striking tethering trimethylated u1242mg	analyze associations bax bcl2 birc5 bladder carcinogenesis ccnd1 ccne1 demonstrates egfr heterozygosity indices intron loh methylation methylscreen papillary polymerase positively reveal reverse suppressor technology transduction tumorigenesis urothelial vegf wwox
Tagcloud (Intersection) ?