TNPO2 and PYCR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNPO2	PYCR1
Description		transportin 2	pyrroline-5-carboxylate reductase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity	Pyrroline-5-carboxylate Reductase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Negative Regulation Of Muscle Cell Differentiation	Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential L-proline Biosynthetic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Pathways			Glutamate and glutamine metabolism
Drugs			NADH Proline
Diseases			Geroderma osteodysplasticum
GWAS		Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)
Interacting Genes		54 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CEBPA CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RBM45 REDIC1 RIPK4 RNF10 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 ZBTB32 ZC2HC1C	7 interacting genes: BNIPL CDK2AP2 FXR1 HNRNPD NUDT21 SIRT3 TNPO2
Entrez ID		30000	5831
HPRD ID		04301	01528
Ensembl ID		ENSG00000105576	ENSG00000183010
Uniprot IDs		O14787 Q05D48	E2QRB3 J3QL32 P32322 Q8TBX0
PDB IDs			2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX 6XOZ 6XP0 6XP1 6XP2 6XP3 8DKG 8TCU 8TCV 8TCW 8TCX 8TCY 8TCZ 8TD0 8TD1 8TD2 8TD3 8TD4 8TD5 8TD6 8TD7 8TD8 8TD9 8TDB 8TDC 8TDD 8VRE
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Binding Calcium/calmodulin-dependent Protein Kinase Activity Protein Homodimerization Activity	MRNA 3'-UTR AU-rich Region Binding Negative Regulation Of MRNA Catabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine MRNA Binding Positive Regulation Of Pro-B Cell Differentiation Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of RNA Catabolic Process Regulation Of Circadian Rhythm Negative Regulation Of MRNA Metabolic Process Circadian Regulation Of Translation Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Histone Deacetylase Binding Nucleus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Lymphoid Progenitor Cell Differentiation Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Metabolic Process MRNA Alternative Polyadenylation Positive Regulation Of Translation Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex RNA Strand Annealing Activity Nuclear Pore Localization Histone Deacetylase Activity, NAD-dependent Regulation Of Growth Rate Response To Rapamycin Regulation Of MRNA Stability Cell Dedifferentiation Intracellular Membraneless Organelle MRNA Cleavage Factor Complex Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Ceramide Biosynthetic Process NAD-dependent Protein Lysine Deacetylase Activity Regulation Of RNA Stability Regulation Of Pro-B Cell Differentiation Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Nuclear Pore Complex Assembly Paraspeckles CRD-mediated MRNA Stabilization
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