SART1 and SRSF4

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		SART1	SRSF4
Description		spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	serine and arginine rich splicing factor 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Sequence-specific MRNA Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Maturation Of 5S RRNA MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Cytotoxic T Cell Differentiation	RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Insulin Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs			Artenimol
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Carotid plaque maximum area ( 32469969) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean area of carotid plaque ( 32469969) Schizophrenia ( 26531332) Tourette syndrome ( 30818990)
Interacting Genes		16 interacting genes: APP CEBPA CHERP FILNC1 HSF2BP IGHE RNF10 SNW1 SRPK2 SRSF4 SUMO2 UBC UBE2I UBL5 WBP4 ZCCHC10	28 interacting genes: CPSF7 DYRK1A ERAL1 FUS GEMIN2 HAP1 HTATSF1 NXF1 PNN PPARGC1A PRPF38A PRRC2B SART1 SCAF11 SMURF1 SMURF2 SREK1 SRPK1 SRRM2 SRRM4 SRSF10 SRSF2 SRSF6 TICAM1 TRA2B UBE2I USP7 ZDHHC17
Entrez ID		9092	6429
HPRD ID		10440	09052
Ensembl ID		ENSG00000175467	ENSG00000116350
Uniprot IDs		O43290	Q08170
PDB IDs		4PYU 5O9Z 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Macromolecule Metabolic Process MRNA Processing RNA Binding RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Processing Regulation Of MRNA Splicing, Via Spliceosome SUMO Transferase Activity RNA Metabolic Process MRNA Metabolic Process Nucleoplasm Regulation Of MRNA Processing Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Proteolysis Protein Modification Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Macrophage Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding IgE B Cell Receptor Complex Nuclear Speck Regulation Of RNA Splicing SUMO Conjugating Enzyme Activity MRNA Splicing, Via Spliceosome Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein Sumoylation Positive Regulation Of Calcium-mediated Signaling Presynapse Acetylcholine Receptor Activator Activity Macrophage Activation Antibacterial Humoral Response Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Acute Inflammatory Response Nucleic Acid Metabolic Process Primary Adaptive Immune Response B Cell Antigen Processing And Presentation Type I Hypersensitivity Glutamatergic Synapse Nucleic Acid Binding Positive Regulation Of Neuron Apoptotic Process PTB Domain Binding	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Binding RNA Splicing, Via Transesterification Reactions Nuclear Speck RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleic Acid Binding Regulation Of MRNA Metabolic Process Spliceosomal Complex Assembly Nucleus Protein-containing Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Protein-containing Complex Organization Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process PML Body Cellular Component Assembly Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Pre-mRNA Binding Presynaptic Cytosol Postsynaptic Cytosol Protein Binding Nuclear Export MRNA Splice Site Recognition Wnt Signaling Pathway, Planar Cell Polarity Pathway Histone H3T45 Kinase Activity SUMO Conjugating Enzyme Activity Positive Regulation Of Neurotrophin Production Maturation Of 5S RRNA Perforant Pathway To Dendrate Granule Cell Synapse Engulfment Of Target By Autophagosome Positive Regulation Of RNA Splicing Regulation Of Amyloid-beta Formation
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