RUSC1 and TBC1D25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RUSC1	TBC1D25
Description		RUN and SH3 domain containing 1	TBC1 domain family member 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Cytoskeleton Microtubule Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Vesicle Synapse	Cytoplasm Autophagosome Cytoplasmic Vesicle
	Molecular Function	Actin Binding Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Protein Polyubiquitination	Autophagy Regulation Of Autophagosome Maturation
Pathways			TBC/RABGAPs
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		92 interacting genes: ABHD11 ABHD5 ABI2 AIRIM AKAP8L ANKS1A APP ATP6V0D2 BPIFA1 CCDC120 CCDC57 CCHCR1 CCNC CDKN2B CMTM6 CREM CRYBA2 CTAG1A CTAG1B DMRT3 DOK6 DTX2 DVL2 EXOC8 EXOSC8 FAM9B FNDC3B GCM2 HMG20A HNRNPF INSC KCTD9 KRTAP19-1 KRTAP19-5 KRTAP6-2 KRTAP8-1 LIMS3 LIMS4 LMO2 MAGEA3 MAGEA6 MAGED1 MED25 MEIS2 MISP MOAP1 MORN3 MYOZ3 N4BP3 NICN1 NTAQ1 NTRK1 NUDT22 OIP5 P4HA3 PFDN5 PIK3R3 PLA2G6 PM20D2 PNMA1 POLR1C PRDM14 PRR35 RBPMS SMARCB1 SMYD1 SOHLH1 SPAG8 STUB1 SUOX TBC1D25 TCHP TEKT4 TENT5B TLE5 TRAPPC6A TRIM55 TRIM63 TRIM73 TSSK3 TTC19 TTC7B UFSP1 VGLL3 WWOX WWP2 ZIC1 ZMYND12 ZNF34 ZNF620 ZNF765 ZNF77	17 interacting genes: FAM9B FEZ1 FEZ2 GABARAP GABARAPL1 GABARAPL2 HMGB2 KCNIP1 LARP1B LGALS14 LMNTD2 MAP1LC3A MAP1LC3B MAP1LC3C RAB2A RUSC1 TRIML2
Entrez ID		23623	4943
HPRD ID		10206	08948
Ensembl ID		ENSG00000160753	ENSG00000068354
Uniprot IDs		A0A8Q3SIT1 B4DQB8 Q9BVN2	B4DF03 Q3MII6
PDB IDs		4GIW
Enriched GO Terms of Interacting Partners?		Protein Binding	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Membrane Autophagosome Maturation Mitophagy Autophagy Of Mitochondrion Macroautophagy Autophagosome Autophagosome Assembly Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Autophagy Vacuole Organization Cellular Response To Starvation Microtubule Response To Starvation Cellular Response To Nutrient Levels Ubiquitin Protein Ligase Binding GABA Receptor Binding Cytoplasmic Vesicle Organelle Assembly Response To Nutrient Levels Beta-tubulin Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Membrane Cytoskeleton Organelle Organization Negative Regulation Of Autophagosome Assembly Cellular Response To Stress Microtubule Binding Endomembrane System Positive Regulation Of Protein Polyubiquitination Transcription Factor Binding Extrinsic Apoptotic Signaling Pathway Cytoplasm Protein-containing Complex Organization Regulation Of Protein Polyubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Catabolic Process Gamma-tubulin Binding Negative Regulation Of Macroautophagy Positive Regulation Of Interferon-beta Production Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Autophagosome Assembly Cellular Component Assembly Regulation Of Interferon-beta Production Golgi Apparatus Regulation Of Vacuole Organization
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