RUSC1 and NTRK1

Number of citations of the paper that reports this interaction (PMID 15024033)
4

Data Source:
HPRD (two hybrid, in vivo)

		RUSC1	NTRK1
Gene Name		RUN and SH3 domain containing 1	neurotrophic tyrosine kinase, receptor, type 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Golgi Apparatus Microtubule Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Cell Junction Cytoplasmic Vesicle Postsynaptic Membrane	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuronal Cell Body Protein Complex Receptor Complex
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Nerve Growth Factor Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Signal Transduction	Activation Of MAPKK Activity Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Aging Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Developmental Programmed Cell Death Positive Regulation Of Neuron Projection Development Response To Activity Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development B Cell Differentiation Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Sympathetic Nervous System Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Axonogenesis Involved In Innervation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Nerve Growth Factor Stimulus
Pathways			Retrograde neurotrophin signalling Signalling to ERKs Signalling by NGF Prolonged ERK activation events Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF PI3K/AKT activation Signalling to RAS Signalling to STAT3 NGF-independant TRKA activation PLC-gamma1 signalling Signalling to p38 via RIT and RIN Frs2-mediated activation
Drugs			Amitriptyline Imatinib Regorafenib
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP FAM9B NTRK1 PNMA1 RBPMS STUB1 WWP2	36 interactors: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 FRS2 FRS3 GIPC1 GRB2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4 NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		23623	4914
HPRD ID		10206	01869
Ensembl ID		ENSG00000160753	ENSG00000198400
Uniprot IDs		B3KWM9 B4DQB8 Q5T9V0 Q9BVN2	P04629
PDB IDs		4GIW	1HE7 1SHC 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5
Enriched GO Terms of Interacting Partners?		Protein K63-linked Ubiquitination Protein Autoubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Synaptic Growth At Neuromuscular Junction Regulation Of Protein Binding Regulation Of Cellular Protein Metabolic Process Collateral Sprouting In Absence Of Injury Protein Polyubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Axonogenesis Involved In Innervation Axon Choice Point Recognition Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Protein Phosphorylation Proteasomal Protein Catabolic Process Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Learning Or Memory Olfactory Nerve Development Cellular Response To Nicotine Cognition Positive Regulation Of Proteolysis Neuron Remodeling Regulation Of Signal Transduction Response To Hydrostatic Pressure Locomotion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Phosphorylation Regulation Of Glucocorticoid Metabolic Process Nerve Growth Factor Signaling Pathway Regulation Of Signaling Positive Regulation Of SMAD Protein Import Into Nucleus Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Axon Guidance Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Response To Misfolded Protein Cellular Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Catalytic Activity Cellular Copper Ion Homeostasis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Kinase Activity Cell Communication Regulation Of Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Catalytic Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Positive Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Response To Stimulus Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Response To Fibroblast Growth Factor Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity
Tagcloud ?			aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Difference) ?			aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Intersection) ?