NOTCH1 and MEF2C

Number of citations of the paper that reports this interaction (PubMedID 10082551)
74

Data Source:
HPRD (in vivo)

		NOTCH1	MEF2C
Description		notch receptor 1	myocyte enhancer factor 2C
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle MAML1-RBP-Jkappa- ICN1 Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Adherens Junction Cell Surface Endosome Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Late Endosome Membrane Receptor Complex Cell Periphery Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Sarcoplasm Nuclear Speck Protein-containing Complex Postsynapse
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Enzyme Inhibitor Activity Transmembrane Signaling Receptor Activity Notch Binding Calcium Ion Binding Protein Binding Enzyme Binding Chromatin DNA Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Transcription Regulator Activator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Luteolysis In Utero Embryonic Development Epithelial To Mesenchymal Transition Liver Development Heart Looping Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Inhibition Of Neuroepithelial Cell Differentiation Inflammatory Response To Antigenic Stimulus Outflow Tract Morphogenesis Endocardium Development Endocardium Morphogenesis Atrioventricular Node Development Coronary Vein Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Coronary Sinus Valve Morphogenesis Pulmonary Valve Morphogenesis Mitral Valve Formation Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Chamber Formation Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Cardiac Right Atrium Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Formation Ventricular Trabecula Myocardium Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Cardioblast Proliferation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Cell Migration Involved In Endocardial Cushion Formation Negative Regulation Of Extracellular Matrix Constituent Secretion Pericardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Immune Response Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Spermatogenesis Determination Of Left/right Symmetry Compartment Pattern Specification Axonogenesis Axon Guidance Foregut Morphogenesis Endoderm Development Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Notch Signaling Pathway Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Glial Cell Differentiation Gene Expression Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Myotube Differentiation Mesenchymal Cell Development Regulation Of Somitogenesis Calcium-ion Regulated Exocytosis Cell Differentiation In Spinal Cord Neural Tube Development Central Nervous System Neuron Differentiation Cell Differentiation Protein Catabolic Process Neuron Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Lung Development Embryonic Limb Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Hair Follicle Morphogenesis Animal Organ Regeneration Response To Muramyl Dipeptide Response To Lipopolysaccharide Negative Regulation Of Collagen Biosynthetic Process Embryonic Hindlimb Morphogenesis Tube Formation Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Population Proliferation Tissue Regeneration Retinal Cone Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Viral Genome Replication Positive Regulation Of Endothelial Cell Differentiation Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Photoreceptor Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction Somatic Stem Cell Division Neuron Fate Commitment Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Venous Blood Vessel Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Glial Cell Proliferation Cilium Assembly Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production Cardiac Muscle Cell Myoblast Differentiation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Prostate Gland Epithelium Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Arterial Endothelial Cell Differentiation Venous Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Endocardial Cell Differentiation Vasculogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Neuroendocrine Cell Differentiation Regulation Of Cell Adhesion Involved In Heart Morphogenesis Heart Trabecula Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Tumor Cell Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Hypoxia Distal Tubule Development Collecting Duct Development Regulation Of Stem Cell Proliferation Glomerular Mesangial Cell Development Epithelial Cell Fate Commitment T-helper 17 Type Immune Response Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance Interleukin-17-mediated Signaling Pathway Chemical Synaptic Transmission, Postsynaptic Negative Regulation Of Cold-induced Thermogenesis Regulation Of Extracellular Matrix Assembly Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Positive Regulation Of Aorta Morphogenesis Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Anoikis Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Endothelial Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Blood Vessel Development Osteoblast Differentiation Neuron Migration B Cell Homeostasis Heart Looping Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Germinal Center Formation Regulation Of Germinal Center Formation Response To Ischemia Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Sinoatrial Valve Morphogenesis Cardiac Ventricle Formation Regulation Of DNA-templated Transcription Apoptotic Process Humoral Immune Response Nervous System Development Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Muscle Cell Fate Determination Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Neural Crest Cell Differentiation Myotube Differentiation Cell Differentiation Neuron Differentiation Platelet Formation Negative Regulation Of Ossification Melanocyte Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of B Cell Proliferation Cellular Response To Trichostatin A B Cell Proliferation Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Megakaryocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Positive Regulation Of Skeletal Muscle Tissue Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation B Cell Receptor Signaling Pathway Smooth Muscle Cell Differentiation Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Ventricular Cardiac Muscle Cell Differentiation Regulation Of Synaptic Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Development Renal Tubule Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Behavioral Fear Response Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Defective LFNG causes SCDO3 RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm NFE2L2 regulating tumorigenic genes Regulation of NFE2L2 gene expression Somitogenesis	ERK/MAPK targets Transcriptional activation of mitochondrial biogenesis Myogenesis MECP2 regulates transcription factors Heme signaling Cardiogenesis Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs
Diseases		Bicuspid aortic valve Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Crohn's disease ( 28067908) Eosinophil count ( 32888494) Inflammatory bowel disease ( 28067908) Length of menstrual cycle ( 26732621) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 28957414) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)	Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Adult body size ( 32376654) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 29325848) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body mass index ( 26426971) Bone mineral density ( 23572186 24249740 21533022) Bone mineral density (hip) ( 19801982) Bone mineral density (total hip) ( 29883787) Bone mineral density (Ward's triangle area) ( 27397699) Caffeine consumption from coffee ( 33287642) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Depression ( 29700475) Femoral neck bone mineral density ( 32239398 29499414 22504420) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) General cognitive ability ( 29844566) Glomerular filtration rate in chronic kidney disease ( 26420894) Height ( 20881960 25282103 25429064) Hematocrit ( 32888494) Hemoglobin ( 32888494) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 27863252 22139419 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Morning person ( 30696823) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Platelet count ( 32888494 27863252 22139419) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Retinal arteriolar caliber ( 23776548) Retinal vascular caliber ( 21060863) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking status (ever vs never smokers) ( 30643258) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Tonometry ( 17903302) Vascular endothelial growth factor levels ( 26910538) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		88 interacting genes: ADAM17 AKT1 APBA1 ARL6IP5 B3GALT4 BLOC1S1 CACNA1A CAMK4 CASR CBL CCN3 CEP57L1 CNTN1 COL4A6 CTNNB1 DAZAP2 DDR1 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 EXT1 FAM185A FBP1 FBXW7 FURIN GFI1B GOLGA2 GOPC GSK3B HMGN5 HOXA1 ILK ITCH JAG1 JAG2 KAT2A KAT2B KIAA1191 LCK LEF1 LFNG LINC00260 LINC00261 LINC02907 LNX2 MAGEA1 MAGED1 MAML1 MAML2 MAML3 MAP3K1 MBD1 MDM2 MEF2C MFNG NFKB1 NLK NUMB NUMBL PIK3CG POFUT1 POU2AF1 PRKCD PSEN1 PSEN2 RBP3 RBPJ REL RELA RHOA RUNX3 SHANK3 SMAD3 SNAI1 SNW1 STC1 TLE3 USP10 USP12 USP2 WDR12 WWP1 XIAP XRCC6 YY1	31 interacting genes: ASCL1 CCNB1 CDK1 COPS5 CSNK2A1 EP300 EPAS1 GATA4 HDAC4 HDAC5 HDAC7 HDAC9 KPNA4 MAPK14 MAPK7 MEF2D MYOD1 MYOG NCOA2 NOTCH1 PLA2G12A SMAD2 SOX18 SP1 SPTBN1 TEAD1 TWIST2 UBE2I VGLL2 VGLL4 YWHAZ
Entrez ID		4851	4208
HPRD ID		01827	02809
Ensembl ID		ENSG00000148400	ENSG00000081189
Uniprot IDs		P46531	A0A0D9SFD0 A0A0D9SGI5 A0A0R4J2G5 A0A9L9PYA3 D8L7E9 Q06413
PDB IDs		1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79 4CUD 4CUE 4CUF 4D0E 4D0F 5FM9 5FMA 5KZO 5L0R 5UB5 6IDF 6PY8 8OR5 8ORY 8ORZ 9B3G 9B3N
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Notch Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Notch Binding Lymphocyte Activation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Signaling Leukocyte Activation Cell Activation Somitogenesis Regulation Of Cell Development Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Segmentation Positive Regulation Of Cell Differentiation Regulation Of Developmental Process Protein Modification Process Mononuclear Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Tissue Morphogenesis Lymphocyte Differentiation Tube Morphogenesis Regulation Of Gene Expression Positive Regulation Of Developmental Process Leukocyte Differentiation Regulation Of RNA Metabolic Process Regionalization Morphogenesis Of An Epithelium Pattern Specification Process Positive Regulation Of Gene Expression Regulation Of Multicellular Organismal Development Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Myotube Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Nucleoplasm DNA-binding Transcription Activator Activity Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Fate Commitment Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Regulation Of Developmental Process Striated Muscle Tissue Development Protein Lysine Deacetylase Activity Negative Regulation Of Metabolic Process Chromatin Regulation Of Cardiac Muscle Cell Proliferation Muscle Tissue Development Regulation Of Muscle Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Histone Deacetylase Activity Heart Development DNA-binding Transcription Factor Activity
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