NOTCH1 and NUMB

  • Number of citations of the paper that reports this interaction (PMID 12682059)
  • 84
  • Data Source:
  • HPRD (in vivo, in vitro)

NOTCH1

NUMB

Gene Name notch 1 numb homolog (Drosophila)
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Bipolar disorder (mood-incongruent) ( 23092984)
  • Coronary artery calcification ( 17903303)
Protein-Protein Interactions 56 interactors: ADAM17 AKT1 APBA1 BLOC1S1 CACNA1A CAMK4 CBL CNTN1 CTNNB1 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 FBXW7 FURIN GFI1B GSK3B ILK ITCH JAG1 JAG2 KAT2A KAT2B LCK LEF1 LFNG MAML1 MAML2 MAML3 MDM2 MEF2C MFNG NFKB1 NOV NUMB NUMBL PIK3CG POFUT1 PSEN1 PSEN2 RBP3 RBPJ REL RELA RUNX3 SMAD3 SNAI1 SNW1 USP12 WDR12 WWP1 XIAP XRCC6 YY1 24 interactors: AP2A1 AP2A2 APP DPYSL2 EGFR EPS15 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MDM2 NOTCH1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ RPL3 SIAH1
Entrez ID 4851 8650
HPRD ID 01827 04767
Ensembl ID ENSG00000148400 ENSG00000133961
Uniprot IDs P46531 P49757
PDB IDs 1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79
Enriched GO Terms of Interacting Partners?
Tagcloud ?
a23187  alpha1  antitrypsin  biologically  carboxyl  cleaved  convertase  convertases  decisions  dibasic  digestion  disagree  exists  extend  fate  furin  heterodimeric  invertebrates  ionophore  lovo  nearby  pdx  processed  processing  proteolytic  rqrr  takes  vertebrates 
adapter  affinities  arise  asymmetric  bind  bond  contain  diverse  division  domain  gp  gppy  helical  hydrogen  ldnpay  library  lnx  modes  motif  nak  nmr  npxy  peptide  phosphotyrosine  ptb  reveals  sheet  turn  y 
Tagcloud (Difference) ?
a23187  alpha1  antitrypsin  biologically  carboxyl  cleaved  convertase  convertases  decisions  dibasic  digestion  disagree  exists  extend  fate  furin  heterodimeric  invertebrates  ionophore  lovo  nearby  pdx  processed  processing  proteolytic  rqrr  takes  vertebrates 
adapter  affinities  arise  asymmetric  bind  bond  contain  diverse  division  domain  gp  gppy  helical  hydrogen  ldnpay  library  lnx  modes  motif  nak  nmr  npxy  peptide  phosphotyrosine  ptb  reveals  sheet  turn  y 
Tagcloud (Intersection) ?