CPSF6 and WWP1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		CPSF6	WWP1
Gene Name		cleavage and polyadenylation specific factor 6, 68kDa	WW domain containing E3 ubiquitin protein ligase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage Factor Complex Membrane Ribonucleoprotein Complex Paraspeckles	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Binding MRNA Binding Protein Binding Poly(A) RNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity
	Biological Process	MRNA Polyadenylation MRNA Processing Protein Tetramerization	Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Transmembrane Transport
Pathways		Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	Downregulation of ERBB4 signaling Ion channel transport Antigen processing: Ubiquitination & Proteasome degradation Stimuli-sensing channels Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Adaptive Immune System
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		23 interactors: APBB1 ARMC7 CSNK2A1 EWSR1 GIN1 ITCH ITSN2 KLHL12 NCK2 NEDD4 NUDT21 OTUB2 PLSCR1 PPIL1 PRPF40A SRSF7 TCERG1 TOLLIP UBAC1 UBQLN4 WBP4 WWP1 WWP2	47 interactors: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 H2AFY2 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PTEN RASA1 RNF11 RTN4 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2L3 WBP1 WBP2 YWHAQ ZNF638
Entrez ID		11052	11059
HPRD ID		05401	03811
Ensembl ID		ENSG00000111605	ENSG00000123124
Uniprot IDs		B4DSU9 Q16630	Q9H0M0
PDB IDs		3P5T 3P6Y 3Q2S 3Q2T 4B4N	1ND7 2OP7
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Interaction With Host Protein K63-linked Ubiquitination Viral Entry Into Host Cell Entry Into Host Cell Locomotion Protein Ubiquitination RNA Splicing Protein Modification By Small Protein Conjugation Cellular Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing RNA Metabolic Process Cellular Protein Modification Process Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Catabolic Process Gene Expression Protein Polyubiquitination Regulation Of Potassium Ion Transmembrane Transport Termination Of RNA Polymerase II Transcription Viral Life Cycle Protein Monoubiquitination Regulation Of RNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Thymidylate Synthase Biosynthetic Process Transmission Of Virus Development Involved In Symbiotic Interaction Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Potassium Ion Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Regulation Of Nitrogen Compound Metabolic Process DNA-templated Transcription, Termination Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process MRNA 3'-end Processing Regulation Of Protein Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Organ Development Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Apoptotic Process Gene Expression Regulation Of Transcription, DNA-templated Programmed Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Death Death Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter System Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Protein Metabolic Process Tube Development Positive Regulation Of Protein Modification Process Multicellular Organismal Development Negative Regulation Of Signaling Tissue Development Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Growth Factor Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Signal Transduction Developmental Process Positive Regulation Of Ligase Activity Epithelium Development
Tagcloud ?		abilities assembled believe bi bi2 ca cai capsid complexes core crowding cyclophilin cyclosporine destabilize destabilized destabilizes extracts fate hiv ixn macromolecular nc pf74 powerful productive solely stability stabilize stabilized	biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous
Tagcloud (Difference) ?		abilities assembled believe bi bi2 ca cai capsid complexes core crowding cyclophilin cyclosporine destabilize destabilized destabilizes extracts fate hiv ixn macromolecular nc pf74 powerful productive solely stability stabilize stabilized	biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous
Tagcloud (Intersection) ?