SIX1 and AES

Number of citations of the paper that reports this interaction (PMID 12441302)
36

Data Source:
HPRD (two hybrid, in vitro)

		SIX1	AES
Gene Name		SIX homeobox 1	amino-terminal enhancer of split
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Growth At Neuromuscular Junction Regulation Of Satellite Cell Proliferation Facial Nerve Morphogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription, DNA-templated Multicellular Organismal Development Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis
Pathways			APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt repression of WNT target genes APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 22419738 22570617) Optic disc size (rim) ( 20395239) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		10 interactors: AES CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI TLE1 VTN	138 interactors: ABI2 AEN AR ARHGAP32 ATN1 BAHD1 BCL6 BHLHE40 BIRC7 BYSL C1orf109 C1orf216 C1orf94 C6orf165 CALCOCO2 CAPN1 CARD9 CCDC57 CCL7 CCNJL CCNK CIB3 CPSF7 CRACR2A CRX CTAGE5 DDX6 DGCR6 DIP2A EAF1 EIF4E2 FAM124A FAM124B FBF1 FOXP2 FRS3 FSD2 GABARAP GFAP GFI1B GOLGA2 GORASP2 GRB2 GTF2E1 HMGB1 HNF1A HNRNPF HOMEZ IKZF3 KANK2 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 L3MBTL2 LDOC1 LINC00526 LMO1 LMO2 LMO4 LSM2 MAGOHB MAPK14 MBNL1 MED31 MED4 MFAP1 MLX MORF4L2 MSX1 MTUS2 MVP MYO15B NAB2 NCDN NEK6 NOTCH2NL NUDT22 OLIG3 OSGIN1 PARVG POU2F1 PPP1R16A PRDM1 PRKAA1 PRKAA2 PRPF31 PRR3 PTRH2 QARS RBM10 RBPMS REL RELA RFX6 RHOXF2 RIMBP3 RNF31 RPL18A RUNX1 SCNM1 SDCBP SH3GL3 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SNCAIP SNRPC SOX5 SRPK2 STK16 STX11 TBX3 TCF4 TMCC2 TRAF1 TRAF2 TRIM26 TRIM27 TRIM41 TSC22D4 TSGA10 TSSK3 U2AF2 UBXN11 VPS37B VPS37C ZBTB24 ZGPAT ZNF576
Entrez ID		6495	166
HPRD ID		03125	02556
Ensembl ID			ENSG00000104964
Uniprot IDs		Q15475	Q08117 Q8WY48
PDB IDs		4EGC
Enriched GO Terms of Interacting Partners?		Histone Dephosphorylation Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Developmental Process Peptidyl-tyrosine Dephosphorylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Dephosphorylation Regulation Of RNA Metabolic Process Embryonic Morphogenesis RNA Metabolic Process Multicellular Organismal Development Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Anoikis Dephosphorylation Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Middle Ear Morphogenesis Nucleobase-containing Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cellular Metabolic Process DNA Repair Chromatin Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Positive Regulation Of DNA Repair Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Binding Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Regulation Of Wnt Signaling Pathway Nitrogen Compound Metabolic Process Embryonic Organ Morphogenesis Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair	RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Multicellular Organismal Development Cellular Metabolic Process Developmental Process Anatomical Structure Development Positive Regulation Of Cellular Biosynthetic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Organ Morphogenesis Embryo Development Tissue Development RNA Processing RNA Splicing In Utero Embryonic Development Regulation Of Cell Death Organ Development
Tagcloud ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six6 srbd1 tmco1 wdr36 zfpm2	auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps
Tagcloud (Difference) ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six6 srbd1 tmco1 wdr36 zfpm2	auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps
Tagcloud (Intersection) ?