SIX1 and EYA3

Number of citations: 35 (PubMedID 12215533)
Data Source: HPRD (in vitro)

		SIX1	EYA3
Name		SIX homeobox 1	EYA transcriptional coactivator and phosphatase 3
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Centrosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Histone H2AXY142 Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Assembly At Neuromuscular Junction Gene Expression Regulation Of Gene Expression Neural Crest Cell Differentiation Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Skeletal Muscle Cell Proliferation Facial Nerve Morphogenesis Neurogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Skeletal Muscle Fiber Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Endothelin Receptor Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Myoblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation	DNA Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Cell Differentiation Positive Regulation Of DNA Repair Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Formation of the ureteric bud	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Diseases		Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)	None
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575 ) Glaucoma ( 31959993 ) Glaucoma (multi-trait analysis) ( 31959993 ) Glaucoma (primary open-angle) ( 22419738 22570617 29891935 ) Gut microbiota (bacterial taxa) ( 27723756 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Optic disc size ( 31809533 ) Optic nerve measurement (rim area) ( 20395239 ) Prostate cancer ( 25217961 ) Refractive error ( 32231278 ) Vertical cup-disc ratio ( 20548946 25241763 )	Plasma trimethylamine N-oxide levels ( 28439531 ) Total cholesterol levels ( 30275531 )
Interacting Genes		14 interacting genes: CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI PLEKHG4 POU6F2 REL TLE1 TLE3 TLE5 VTN	9 interacting genes: CRK DACH1 DSCAM DSCR9 SIX1 SIX2 SIX4 SIX5 ZDHHC17
Entrez ID		6495	2140
HPRD ID		03125	09042
Ensembl ID		ENSG00000126778	ENSG00000158161
Uniprot IDs		Q15475	Q99504
PDB IDs		4EGC	Not available
GO Terms Enriched among Interactors		Histone H2AXY142 Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Phosphoprotein Phosphatase Activity Positive Regulation Of DNA Repair Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Mesodermal Cell Fate Specification Developmental Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Apoptotic Signaling Pathway Beta-catenin-TCF Complex Positive Regulation Of DNA Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Process Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Negative Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Transcription Corepressor Activity Anatomical Structure Morphogenesis DNA Repair Regulation Of Programmed Cell Death	Transcription Regulator Complex Regulation Of Branching Involved In Ureteric Bud Morphogenesis Fungiform Papilla Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Regulation Of Kidney Development Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development Cranial Ganglion Development Regulation Of Morphogenesis Of A Branching Structure Tongue Development Regulation Of Morphogenesis Of An Epithelium Metanephric Mesenchyme Development Regulation Of Animal Organ Morphogenesis Embryonic Skeletal System Morphogenesis Positive Regulation Of Epithelial Tube Formation Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Population Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Myoblast Migration Skeletal System Morphogenesis Regulation Of Skeletal Muscle Cell Proliferation Ganglion Development Embryonic Organ Morphogenesis Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Pharyngeal System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Generation Of Neurons Middle Ear Morphogenesis Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Cell Differentiation Mesenchymal Cell Proliferation Muscle Cell Migration Protein Localization To Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Growth Positive Regulation Of Morphogenesis Of An Epithelium Protein Tyrosine Kinase Binding DNA-binding Transcription Factor Activity Thymus Development Developmental Process Anatomical Structure Morphogenesis Mesenchyme Development Regulation Of Synapse Organization Inner Ear Morphogenesis Regulation Of Transcription By RNA Polymerase II