SIX1 and EYA4

Number of citations of the paper that reports this interaction (PMID 15492887)
6

Data Source:
HPRD (two hybrid, in vivo)

		SIX1	EYA4
Gene Name		SIX homeobox 1	EYA transcriptional coactivator and phosphatase 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Growth At Neuromuscular Junction Regulation Of Satellite Cell Proliferation Facial Nerve Morphogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation	DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Visual Perception Sensory Perception Of Sound Anatomical Structure Morphogenesis Chromatin Modification Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 22419738 22570617) Optic disc size (rim) ( 20395239) Vertical cup-disc ratio ( 20548946)	Protein quantitative trait loci ( 18464913) Response to angiotensin II receptor blocker therapy ( 22566498) Visceral fat ( 22589738)
Protein-Protein Interactions		10 interactors: AES CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI TLE1 VTN	1 interactors: SIX1
Entrez ID		6495	2070
HPRD ID		03125	04648
Ensembl ID			ENSG00000112319
Uniprot IDs		Q15475	E7ESD5 E9PLN6 F2Z2Y1 O95677 Q96CJ7
PDB IDs		4EGC
Enriched GO Terms of Interacting Partners?		Histone Dephosphorylation Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Developmental Process Peptidyl-tyrosine Dephosphorylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Dephosphorylation Regulation Of RNA Metabolic Process Embryonic Morphogenesis RNA Metabolic Process Multicellular Organismal Development Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Anoikis Dephosphorylation Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Middle Ear Morphogenesis Nucleobase-containing Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cellular Metabolic Process DNA Repair Chromatin Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Positive Regulation Of DNA Repair Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Binding Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Regulation Of Wnt Signaling Pathway Nitrogen Compound Metabolic Process Embryonic Organ Morphogenesis Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair	Positive Regulation Of Ureteric Bud Formation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Myotome Development Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Ureter Smooth Muscle Cell Differentiation Olfactory Placode Formation Trigeminal Ganglion Development Regulation Of Satellite Cell Proliferation Mesonephric Tubule Formation Regulation Of Secondary Heart Field Cardioblast Proliferation Facial Nerve Morphogenesis Myoblast Migration Fungiform Papilla Morphogenesis Fungiform Papilla Development Ureter Development Ganglion Development Otic Vesicle Development Regulation Of Skeletal Muscle Cell Differentiation Metanephric Mesenchyme Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Parasympathetic Nervous System Development Nephron Tubule Formation Tongue Morphogenesis Nose Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Pharyngeal System Development Cochlea Morphogenesis Aorta Morphogenesis Middle Ear Morphogenesis Thyroid Gland Development Aorta Development Smooth Muscle Tissue Development Neuron Fate Specification Positive Regulation Of Embryonic Development Regulation Of Heart Morphogenesis Positive Regulation Of Kidney Development Organ Induction Tongue Development Muscle Cell Migration Positive Regulation Of Mesenchymal Cell Proliferation Autonomic Nervous System Development Regulation Of Mesenchymal Cell Proliferation Cochlea Development Developmental Induction Regulation Of Organ Formation Cranial Nerve Development Smooth Muscle Cell Differentiation
Tagcloud ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six6 srbd1 tmco1 wdr36 zfpm2	ascl2 c4b dab2ip dlk1 fabp3 fzd9 gas7 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Difference) ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six6 srbd1 tmco1 wdr36 zfpm2	ascl2 c4b dab2ip dlk1 fabp3 fzd9 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Intersection) ?		gas7