SIX1 and TLE3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SIX1	TLE3
Description		SIX homeobox 1	TLE family member 3, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Assembly At Neuromuscular Junction Gene Expression Regulation Of Gene Expression Neural Crest Cell Differentiation Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Skeletal Muscle Cell Proliferation Facial Nerve Morphogenesis Neurogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Skeletal Muscle Fiber Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Endothelin Receptor Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Myoblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis
Pathways		Formation of the ureteric bud	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
Drugs
Diseases		Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 22419738 22570617 29891935) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Optic disc size ( 31809533) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946 25241763)	Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340 28552196 25282103) Hip circumference adjusted for BMI ( 34021172) L-selectin levels ( 25576479) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Monocyte percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 32439900 30046033) Pulmonary function ( 23932459) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Schizophrenia ( 30285260 29483656 25056061) Serum total protein levels ( 29403010) Triglyceride levels ( 29403010 33339817) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI PLEKHG4 POU6F2 REL TLE1 TLE3 TLE5 VTN	17 interacting genes: APP CHERP CSTF2 FBXO7 FOXG1 H2AC1 H3C1 H4C1 HINFP KRTAP15-1 NDRG1 NOTCH1 PIN1 SIX1 SIX3 TCF4 USP47
Entrez ID		6495	7090
HPRD ID		03125	02558
Ensembl ID		ENSG00000126778	ENSG00000140332
Uniprot IDs		Q15475	B3KUA2 H0YL70 Q04726 Q6PRX3
PDB IDs		4EGC
Enriched GO Terms of Interacting Partners?		Histone H2AXY142 Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Phosphoprotein Phosphatase Activity Positive Regulation Of DNA Repair Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Mesodermal Cell Fate Specification Developmental Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Apoptotic Signaling Pathway Beta-catenin-TCF Complex Positive Regulation Of DNA Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Process Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Negative Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Transcription Corepressor Activity Anatomical Structure Morphogenesis DNA Repair Regulation Of Programmed Cell Death	Protein Heterodimerization Activity Regulation Of Neuron Differentiation Nucleus Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Axon Midline Choice Point Recognition Regulation Of Neuroblast Proliferation Regulation Of Cell Cycle Process Axon Choice Point Recognition Regulation Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Regulation Of Cardioblast Proliferation Establishment Of Protein Localization To Organelle Mitogen-activated Protein Kinase Kinase Binding Apoptotic Process Nucleoplasm Negative Regulation Of Neuron Differentiation Cell Death Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Protein Targeting Structural Constituent Of Chromatin Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neuron Differentiation Regulation Of Neural Precursor Cell Proliferation Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Notch Signaling Pathway Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Cycle Process Epithelial Cell Maturation Nucleosome Cellular Developmental Process Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Survivin Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of RNA Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Cell Maturation Positive Regulation Of Toll Signaling Pathway
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