SIX1 and EYA1

Number of citations of the paper that reports this interaction (PMID 12874121)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, two hybrid, in vitro)

		SIX1	EYA1
Gene Name		SIX homeobox 1	EYA transcriptional coactivator and phosphatase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	RNA Binding Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Growth At Neuromuscular Junction Regulation Of Satellite Cell Proliferation Facial Nerve Morphogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation	Establishment Of Mitotic Spindle Orientation Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Double-strand Break Repair Transcription, DNA-templated Pattern Specification Process Sensory Perception Of Sound Anatomical Structure Morphogenesis Response To Ionizing Radiation Striated Muscle Tissue Development Histone Dephosphorylation Protein Sumoylation Cellular Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Peptidyl-tyrosine Dephosphorylation Aorta Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Pharyngeal System Development Lung Epithelial Cell Differentiation Otic Vesicle Morphogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 22419738 22570617) Optic disc size (rim) ( 20395239) Vertical cup-disc ratio ( 20548946)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Sleepiness ( 17903308)
Protein-Protein Interactions		10 interactors: AES CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI TLE1 VTN	7 interactors: DACH1 GNAI2 GNAZ GSK3B SIX1 SIX2 SIX3
Entrez ID		6495	2138
HPRD ID		03125	03388
Ensembl ID			ENSG00000104313
Uniprot IDs		Q15475	A6NCB9 Q99502
PDB IDs		4EGC
Enriched GO Terms of Interacting Partners?		Histone Dephosphorylation Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Developmental Process Peptidyl-tyrosine Dephosphorylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Dephosphorylation Regulation Of RNA Metabolic Process Embryonic Morphogenesis RNA Metabolic Process Multicellular Organismal Development Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Anoikis Dephosphorylation Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Middle Ear Morphogenesis Nucleobase-containing Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cellular Metabolic Process DNA Repair Chromatin Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Positive Regulation Of DNA Repair Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Binding Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Regulation Of Wnt Signaling Pathway Nitrogen Compound Metabolic Process Embryonic Organ Morphogenesis Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair	Protein Localization To Organelle Negative Regulation Of Biosynthetic Process Protein Localization To Nucleus Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Cell Proliferation Mesenchyme Development Middle Ear Morphogenesis Cell Proliferation Nucleocytoplasmic Transport Nuclear Transport Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Commitment Cell Motility Stem Cell Differentiation Embryonic Organ Morphogenesis Developmental Induction Negative Regulation Of Cellular Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Locomotion Nephron Morphogenesis Positive Regulation Of Cellular Metabolic Process Pattern Specification Process Embryonic Organ Development Positive Regulation Of Transcription, DNA-templated Neuroblast Migration Mesenchymal Stem Cell Proliferation Cellular Protein Localization Cell Fate Specification Epithelial Cell Differentiation Kidney Morphogenesis Regulation Of Neuron Differentiation Metanephros Development Movement Of Cell Or Subcellular Component Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Stem Cell Proliferation Axis Specification Sensory Organ Development Positive Regulation Of Gene Expression Protein Import Into Nucleus Nuclear Import Ear Morphogenesis Regulation Of Cell Differentiation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development
Tagcloud ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six6 srbd1 tmco1 wdr36 zfpm2	amphiphysin bmp7 bred cited1 e13 e15 endowment ensures gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 six2 superficially susceptibile thinning wnt4
Tagcloud (Difference) ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six6 srbd1 tmco1 wdr36 zfpm2	amphiphysin bmp7 bred cited1 e13 e15 endowment ensures gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 six2 superficially susceptibile thinning wnt4
Tagcloud (Intersection) ?