CRIPTO and GDF3

Number of citations of the paper that reports this interaction (PubMedID 28126904)
67

Data Source:
BioGRID (pull down)

		CRIPTO	GDF3
Description		cripto, EGF-CFC family member	growth differentiation factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Membrane Raft Side Of Membrane	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding	Cytokine Activity Growth Factor Activity Protein Kinase Binding
	Biological Process	Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Type II Interferon Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	Skeletal System Development Eye Development In Utero Embryonic Development Response To Dietary Excess Signal Transduction Endoderm Development Mesoderm Development Regulation Of Cell Fate Commitment BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Notochord Development Somite Rostral/caudal Axis Specification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Animal Organ Development Formation Of Anatomical Boundary Primitive Streak Formation Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Pathways		Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases			Anophthalmia and microphthalmia (A/M) Klippel-Feil syndrome(KFS)
GWAS			Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2	1 interacting genes: CRIPTO
Entrez ID		6997	9573
HPRD ID		01757	05938
Ensembl ID		ENSG00000241186	ENSG00000184344
Uniprot IDs		F5H1T8 P13385	Q9NR23
PDB IDs
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Cellular Response To BMP Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization Response To Growth Factor Activin Receptor Activity, Type I Activin Binding Cell Surface Receptor Signaling Pathway Activin Receptor Activity Regulation Of Osteoblast Differentiation Growth Factor Binding Mesoderm Formation System Development Lung Development Mesoderm Development Animal Organ Development Regulation Of Multicellular Organismal Development Formation Of Primary Germ Layer BMP Receptor Activity Osteoblast Differentiation Outflow Tract Septum Morphogenesis Tissue Development Cardiac Septum Morphogenesis Growth Factor Activity Pattern Specification Process Heart Development Regulation Of Multicellular Organismal Process Activin Receptor Activity, Type II Regulation Of Reproductive Process Positive Regulation Of Cell Differentiation Developmental Process Involved In Reproduction Gastrulation Gastrulation With Mouth Forming Second Cytokine Activity Heart Valve Morphogenesis	Activin Receptor Binding Response To Hepatocyte Growth Factor Nodal Signaling Pathway Anterior/posterior Axis Specification, Embryo Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Binding Cellular Response To Interleukin-6 Mammary Gland Development Positive Regulation Of MAP Kinase Activity Blood Vessel Endothelial Cell Migration Anterior/posterior Axis Specification Response To Interleukin-6 Activin Receptor Signaling Pathway Cell Migration Involved In Sprouting Angiogenesis Embryonic Axis Specification Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Embryonic Pattern Specification Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Type II Interferon Axis Specification Determination Of Bilateral Symmetry Endothelial Cell Migration Determination Of Left/right Symmetry Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Endothelial Cell Migration Side Of Membrane Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Blood Vessel Development Anterior/posterior Pattern Specification Morphogenesis Of A Branching Structure Growth Factor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Endothelial Cell Migration Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Membrane Raft Regulation Of Protein Kinase Activity Heart Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Phosphorylation
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