CRIPTO and AP2S1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CRIPTO	AP2S1
Description		cripto, EGF-CFC family member	adaptor related protein complex 2 subunit sigma 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Membrane Raft Side Of Membrane	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Intracellular Membrane-bounded Organelle Synapse Clathrin-coated Endocytic Vesicle Presynapse Postsynapse
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Type II Interferon Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579) Low density lipoprotein cholesterol levels ( 32154731) Spondylosis ( 33332786)
Interacting Genes		22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2	6 interacting genes: AAGAB AP2A1 AP2B1 CRIPTO RNF41 UBC
Entrez ID		6997	1175
HPRD ID		01757	03762
Ensembl ID		ENSG00000241186	ENSG00000042753
Uniprot IDs		F5H1T8 P13385	M0QYZ2 M0R0N4 P53680 X6R390
PDB IDs			6URI
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Cellular Response To BMP Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization Response To Growth Factor Activin Receptor Activity, Type I Activin Binding Cell Surface Receptor Signaling Pathway Activin Receptor Activity Regulation Of Osteoblast Differentiation Growth Factor Binding Mesoderm Formation System Development Lung Development Mesoderm Development Animal Organ Development Regulation Of Multicellular Organismal Development Formation Of Primary Germ Layer BMP Receptor Activity Osteoblast Differentiation Outflow Tract Septum Morphogenesis Tissue Development Cardiac Septum Morphogenesis Growth Factor Activity Pattern Specification Process Heart Development Regulation Of Multicellular Organismal Process Activin Receptor Activity, Type II Regulation Of Reproductive Process Positive Regulation Of Cell Differentiation Developmental Process Involved In Reproduction Gastrulation Gastrulation With Mouth Forming Second Cytokine Activity Heart Valve Morphogenesis	Endocytic Vesicle Membrane Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Endocytic Zone AP-2 Adaptor Complex Clathrin Adaptor Complex Clathrin Adaptor Activity Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Coat Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Vesicle-mediated Transport In Synapse Cytoplasmic Side Of Plasma Membrane Interleukin-3 Receptor Binding Synaptic Vesicle Nodal Binding Erythropoietin Receptor Binding Blood Vessel Development Positive Regulation Of Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Signal Sequence Binding Receptor-mediated Endocytosis Extrinsic Component Of Presynaptic Endocytic Zone Membrane Clathrin Coat Activin Receptor Binding Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Heart Development Anterior/posterior Axis Specification, Embryo Protein Transport Nodal Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Endocytosis Golgi To Endosome Transport Cellular Response To Hepatocyte Growth Factor Stimulus Protein Tag Activity Response To Hepatocyte Growth Factor Cellular Response To Interleukin-6 Filopodium Tip Protein-containing Complex Binding Apical Plasma Membrane Establishment Of Protein Localization Clathrin Coat Assembly Response To Interleukin-6 Endoplasmic Reticulum Tubular Network
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