TDGF1 and AP2S1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TDGF1	AP2S1
Gene Name		teratocarcinoma-derived growth factor 1	adaptor-related protein complex 2, sigma 1 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Receptor Binding Protein Binding Growth Factor Activity	Transporter Activity Protein Transporter Activity Clathrin Adaptor Activity
	Biological Process	Activation Of MAPK Activity Vasculogenesis In Utero Embryonic Development Morphogenesis Of A Branching Structure Positive Regulation Of Cell-matrix Adhesion Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Gastrulation Heart Development Positive Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Somatic Stem Cell Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cardiac Muscle Cell Differentiation Canonical Wnt Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Clathrin Coat Assembly Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis
Pathways		Transcriptional regulation of pluripotent stem cells Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by NODAL	Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ACVR1B ACVR1C ANG AP2S1 BAG6 COPS6 FARSA FBLN1 GDF9 LRIF1	4 interactors: AAGAB AP2A1 AP2B1 TDGF1
Entrez ID		6997	1175
HPRD ID		01757	03762
Ensembl ID		ENSG00000241186	ENSG00000042753
Uniprot IDs		F5H1T8 P13385	M0QYZ2 P53680
PDB IDs
Enriched GO Terms of Interacting Partners?		Nodal Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Reproductive Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Oocyte Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Oogenesis Negative Regulation Of Chorionic Trophoblast Cell Proliferation Positive Regulation Of Trophoblast Cell Migration Oocyte Growth Female Gamete Generation Single Organism Reproductive Process Development Of Primary Female Sexual Characteristics Regulation Of Chorionic Trophoblast Cell Proliferation Negative Regulation Of Trophoblast Cell Migration Viral Process Positive Regulation Of Peptidase Activity Diacylglycerol Biosynthetic Process Phenylalanyl-tRNA Aminoacylation Activation Of Phospholipase A2 Activity Regulation Of Progesterone Secretion Negative Regulation Of Cell Growth Regulation Of Secretion Positive Regulation Of Phospholipase A2 Activity Gamete Generation Developmental Process Regulation Of Proteolysis Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Protein Insertion Into ER Membrane Cullin Deneddylation Sexual Reproduction Multicellular Organismal Reproductive Process Development Of Primary Sexual Characteristics Multicellular Organism Reproduction Negative Regulation Of Growth Positive Regulation Of Phosphorylation Protein Deneddylation Germ Cell Development	Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Ephrin Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Hyaluronan Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signaling Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Locomotion Protein Transport Antigen Processing And Presentation Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Receptor-mediated Endocytosis Cellular Response To Hepatocyte Growth Factor Stimulus Axon Guidance Cell Development Cellular Response To Organic Substance Protein Localization Golgi To Endosome Transport Immune System Process Axonogenesis Anterior/posterior Axis Specification, Embryo Viral Process Axon Development Cell Migration Involved In Sprouting Angiogenesis Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Chemotaxis Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Interleukin-6 Endocytosis Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tagcloud ?		altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate	arg15leu argue attempting calcium casr catch causative feeding fhh fhh3 formula gna11 hypercalcemia hypercalciuria hyperparathyroidism hypocalciuria hypocalciuric imply infant infantile necessarily neoplasm payne played presumably pth pthrp sensing worth
Tagcloud (Difference) ?		altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate	arg15leu argue attempting calcium casr catch causative feeding fhh fhh3 formula gna11 hypercalcemia hypercalciuria hyperparathyroidism hypocalciuria hypocalciuric imply infant infantile necessarily neoplasm payne played presumably pth pthrp sensing worth
Tagcloud (Intersection) ?