CDH1 and CDK8

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		CDH1	CDK8
Description		cadherin 1	cyclin dependent kinase 8
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Mediator Complex Protein-containing Complex CKM Complex
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Desmosome Assembly Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Neuron Projection Development Cell Junction Assembly Adherens Junction Organization Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of DNA-templated Transcription Regulation Of Transport Cellular Response To Lithium Ion Response To Heparin Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Response To Gram-positive Bacterium Positive Regulation Of Protein Localization	Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH1 Function Regulation of CDH1 mRNA translation by microRNAs Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of definitive endoderm Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs			Alvocidib
Diseases		Penile cancer Breast cancer Gastric cancer Nasopharyngeal cancer Hepatocellular carcinoma Thyroid cancer
GWAS		Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428 32341527) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Nevus count or cutaneous melanoma ( 32341527) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Ulcerative colitis ( 19915572)	Immune response to measles-mumps-rubella vaccine ( 24811271) Sporadic pituitary adenoma ( 26029870)
Interacting Genes		74 interacting genes: ACTR3 AKT1 ANAPC7 AOPEP ARHGAP32 ARVCF AURKB CA9 CASP3 CASP8 CBLL1 CCNB1 CDC42 CDK8 CHEK1 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 DNMT3A EGFR ERBIN EZR FADD FARP2 FER FGFR1 FYN GALNT12 GNA12 GNA13 GSK3B HDAC1 HDAC2 HEMGN HRAS HSD17B3 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MAP2K1 MAPK3 MKI67 MSANTD3 MYO6 NANS NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM PTTG1 RAB8B RRM2 SFRP2 STX17 TMOD1 UCA1 UCHL3 VCL YES1 ZNF510	39 interacting genes: AURKA BCL6 BMPR1A BUB1 CCNC CCND1 CCNH CDH1 CDKN2B CEBPA CTDP1 ERBB2 ERCC3 ESR1 ESR2 H3C14 KRAS MAML1 MBP MCC MED12 MED21 MED25 MED26 MED8 MED9 MLH3 MYC NRIP1 POLR2A PRMT5 SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53 WDR77
Entrez ID		999	1024
HPRD ID		01885	04422
Ensembl ID		ENSG00000039068	ENSG00000132964
Uniprot IDs		A0A0U2ZQU7 B3GN61 P12830 Q9UII7	P49336
PDB IDs		1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG 6VEL 7STZ 8H62	3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41 6TPA 6Y0A 8TQ2 8TQC 8TQW 9H8C 9H8S
Enriched GO Terms of Interacting Partners?		Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cell Motility Regulation Of Cell Migration Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Cytoplasm Focal Adhesion Cadherin Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Anchoring Junction Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Cell Cortex Negative Regulation Of Apoptotic Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Protein Catabolic Process Regulation Of Cell Adhesion Regulation Of Protein Metabolic Process Positive Regulation Of Cell Migration Cell Motility Regulation Of Cell Population Proliferation Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Cycle Nucleus Positive Regulation Of Cell Motility Negative Regulation Of Cell Motility Cytosol Cytoskeleton Positive Regulation Of Locomotion ERBB Signaling Pathway Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Organization	Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Mediator Complex Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Differentiation Nucleus Chromatin Binding Transcription Preinitiation Complex Assembly Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Cell Population Proliferation Animal Organ Development Regulation Of MiRNA Metabolic Process RNA Polymerase II Preinitiation Complex Assembly DNA-templated Transcription Animal Organ Regeneration Positive Regulation Of MiRNA Transcription Core Mediator Complex Liver Development Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Cell Population Proliferation Gland Development Protein-DNA Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Differentiation
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