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CDH1 and ANAPC7
Number of citations of the paper that reports this interaction (PubMedID
12956947
)
0
Data Source:
HPRD
(in vitro)
CDH1
ANAPC7
Description
cadherin 1
anaphase promoting complex subunit 7
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Endosome
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Adherens Junction
Cytoplasmic Side Of Plasma Membrane
Actin Cytoskeleton
Membrane
Lateral Plasma Membrane
Catenin Complex
Flotillin Complex
Lamellipodium
Cell Junction
Desmosome
Cortical Actin Cytoskeleton
Apical Junction Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Anchoring Junction
Postsynapse
Glutamatergic Synapse
Heterochromatin
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytoplasm
Spindle
Cytosol
Cytoskeleton
Microtubule Cytoskeleton
Intercellular Bridge
Mitotic Spindle
Molecular Function
Calcium Ion Binding
Protein Binding
Beta-catenin Binding
Ankyrin Binding
GTPase Activating Protein Binding
Identical Protein Binding
Gamma-catenin Binding
Cadherin Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Cell-cell Adhesion Mediator Activity
Protein Tyrosine Kinase Binding
Protein Phosphatase Binding
Enzyme-substrate Adaptor Activity
Biological Process
Cell Morphogenesis
Desmosome Assembly
Cell-cell Junction Assembly
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Synapse Assembly
Response To Xenobiotic Stimulus
Response To Toxic Substance
Regulation Of Gene Expression
Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Cell Migration
Pituitary Gland Development
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Neuron Projection Development
Cell Junction Assembly
Adherens Junction Organization
Positive Regulation Of Protein Import Into Nucleus
Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of DNA-templated Transcription
Regulation Of Transport
Cellular Response To Lithium Ion
Response To Heparin
Cellular Response To Indole-3-methanol
Protein Localization To Plasma Membrane
Cell-cell Adhesion
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Response To Gram-positive Bacterium
Positive Regulation Of Protein Localization
Regulation Of Mitotic Cell Cycle
Brain Development
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cell Division
Regulation Of Meiotic Cell Cycle
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein Branched Polyubiquitination
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Apoptotic cleavage of cell adhesion proteins
Adherens junctions interactions
RHO GTPases activate IQGAPs
InlA-mediated entry of Listeria monocytogenes into host cells
Regulation of CDH1 Function
Regulation of CDH1 mRNA translation by microRNAs
Degradation of CDH1
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Formation of definitive endoderm
Transcriptional and post-translational regulation of MITF-M expression and activity
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Myoepithelial Cells
Developmental Lineage of Mammary Stem Cells
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Penile cancer
Breast cancer
Gastric cancer
Nasopharyngeal cancer
Hepatocellular carcinoma
Thyroid cancer
GWAS
Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease (
34020725
)
Colorectal cancer (
19011631
)
Colorectal cancer or advanced adenoma (
30510241
)
Cutaneous malignant melanoma (
26237428
32341527
)
Glycated hemoglobin levels (
34059833
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
32888494
)
Late-onset Alzheimer's disease (
27770636
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Nevus count or cutaneous melanoma (
32341527
)
Red cell distribution width (
32888494
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Ulcerative colitis (
19915572
)
Bipolar disorder (
31043756
)
QT interval (
30679814
)
Schizophrenia (
28991256
)
Total intracranial volume (
31530798
)
Interacting Genes
74 interacting genes:
ACTR3
AKT1
ANAPC7
AOPEP
ARHGAP32
ARVCF
AURKB
CA9
CASP3
CASP8
CBLL1
CCNB1
CDC42
CDK8
CHEK1
CSE1L
CSNK2A1
CTNNA1
CTNNB1
CTNND1
CTNND2
DNMT3A
EGFR
ERBIN
EZR
FADD
FARP2
FER
FGFR1
FYN
GALNT12
GNA12
GNA13
GSK3B
HDAC1
HDAC2
HEMGN
HRAS
HSD17B3
IQGAP1
IRS1
ITGAE
ITGB7
JUP
KEAP1
MAD2L2
MAP2K1
MAPK3
MKI67
MSANTD3
MYO6
NANS
NDRG1
NEDD9
NFE2L2
PIP5K1C
PKD1
PKP4
PPP1CA
PSEN1
PTPN14
PTPRF
PTPRM
PTTG1
RAB8B
RRM2
SFRP2
STX17
TMOD1
UCA1
UCHL3
VCL
YES1
ZNF510
18 interacting genes:
ANAPC10
ANAPC2
BUB1B
CDC16
CDC20
CDC27
CDH1
CDT1
CEBPA
CREBBP
FBXO5
FZR1
HSPB1
OGT
PTEN
PTGER4
UBC
UBE2S
Entrez ID
999
51434
HPRD ID
01885
16233
Ensembl ID
ENSG00000039068
ENSG00000196510
Uniprot IDs
A0A0U2ZQU7
B3GN61
P12830
Q9UII7
Q4KMX6
Q9UJX3
PDB IDs
1O6S
2O72
2OMT
2OMU
2OMV
2OMX
2OMY
2OMZ
3FF7
3FF8
3L6X
3L6Y
4ZT1
4ZTE
6CXY
6OLE
6OLF
6OLG
6VEL
7STZ
8H62
3FFL
4UI9
5A31
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
6TNT
8PKP
8TAR
8TAU
9GAW
Enriched GO Terms of Interacting Partners
?
Cell-cell Adhesion
Adherens Junction
Cell Adhesion
Regulation Of Cell Motility
Regulation Of Cell Migration
Regulation Of Locomotion
Cell Surface Receptor Signaling Pathway
Cytoplasm
Focal Adhesion
Cadherin Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Junction
Regulation Of Signal Transduction
Intracellular Signal Transduction
Signal Transduction
Anchoring Junction
Regulation Of Signaling
Regulation Of Cell Communication
Plasma Membrane
Regulation Of Apoptotic Signaling Pathway
Regulation Of Cell Projection Organization
Regulation Of Mitotic Cell Cycle
Response To Xenobiotic Stimulus
Cell Cortex
Negative Regulation Of Apoptotic Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Protein Catabolic Process
Regulation Of Cell Adhesion
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Migration
Cell Motility
Regulation Of Cell Population Proliferation
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Cell Cycle
Nucleus
Positive Regulation Of Cell Motility
Negative Regulation Of Cell Motility
Cytosol
Cytoskeleton
Positive Regulation Of Locomotion
ERBB Signaling Pathway
Cell Migration
Positive Regulation Of Signal Transduction
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Component Organization
Anaphase-promoting Complex
Anaphase-promoting Complex-dependent Catabolic Process
Anaphase-promoting Complex Binding
Regulation Of Meiotic Cell Cycle
Protein K11-linked Ubiquitination
Cell Division
Metaphase/anaphase Transition Of Cell Cycle
Regulation Of Reproductive Process
Regulation Of Mitotic Cell Cycle
Regulation Of Sister Chromatid Segregation
Regulation Of Cell Cycle
Protein Branched Polyubiquitination
Post-translational Protein Modification
Regulation Of Chromosome Segregation
Protein Ubiquitination
Protein Modification Process
Regulation Of Ubiquitin-protein Transferase Activity
Protein Modification By Small Protein Conjugation
Positive Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Cell Cycle Process
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Modification-dependent Protein Catabolic Process
Negative Regulation Of Cell Cycle Phase Transition
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Spindle
Regulation Of Chromosome Organization
Ubiquitin Ligase Activator Activity
Regulation Of Cell Cycle Phase Transition
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Cell Cycle Process
Nucleoplasm
Regulation Of Nuclear Division
Protein Polyubiquitination
Proteasomal Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Intracellular Signal Transduction
Regulation Of Mitotic Sister Chromatid Separation
Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Chromosome Separation
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Component Organization
Proteolysis
Regulation Of Organelle Organization
Regulation Of Protein Ubiquitination
Negative Regulation Of Cellular Senescence
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Tagcloud (Intersection)
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