CDH1 and ITGAE

Number of citations of the paper that reports this interaction (PMID 12434297)
3

Data Source:
HPRD (in vivo)

		CDH1	ITGAE
Gene Name		cadherin 1, type 1, E-cadherin (epithelial)	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cell-cell Adherens Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Aggresome Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Cell Junction Node Of Ranvier Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Axon Terminus Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integrin Complex External Side Of Plasma Membrane
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Protein Domain Specific Binding Ankyrin Binding GTPase Activating Protein Binding Gamma-catenin Binding Cell Adhesion Molecule Binding	Metal Ion Binding
	Biological Process	Trophectodermal Cell Differentiation Epithelial Cell Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Sensory Perception Of Sound Response To Toxic Substance Single Organismal Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Protein Metabolic Process Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neuron Projection Development Regulation Of Water Loss Via Skin Cell Junction Assembly Adherens Junction Organization Response To Drug Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Regulation Of Immune Response Protein Homooligomerization Intestinal Epithelial Cell Development Salivary Gland Cavitation Regulation Of Branching Involved In Salivary Gland Morphogenesis Tight Junction Assembly Cellular Response To Amino Acid Stimulus Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Development Regulation Of Protein Localization To Cell Surface Regulation Of Neuron Migration	Cell Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization
Pathways		Cell junction organization Apoptotic cleavage of cellular proteins Adherens junctions interactions Apoptotic execution phase Degradation of the extracellular matrix Apoptotic cleavage of cell adhesion proteins Cell-cell junction organization Programmed Cell Death Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Integrin cell surface interactions
Drugs
Diseases
GWAS		Colorectal cancer ( 19011631) Ulcerative colitis ( 19915572)	Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		55 interactors: ACTR3 ANAPC1 ANAPC11 ANAPC4 ANAPC7 ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC16 CDC23 CDC26 CDC42 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBB2IP EZR FER FYN GNA12 GNA13 GSK3B HDAC1 HDAC2 IQGAP1 IRS1 ITGAE ITGB7 JUP MAD2L2 MDM2 NDRG1 NEDD9 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SKP2 TACC3 UCHL3 VCL YES1	4 interactors: CDH1 CHFR EED ITGB7
Entrez ID		999	3682
HPRD ID		01885	05249
Ensembl ID		ENSG00000039068	ENSG00000083457
Uniprot IDs		P12830 Q9UII8	P38570
PDB IDs		1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Adhesion Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Mitotic Spindle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Chromosome Segregation Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Anatomical Structure Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Positive Regulation Of Proteolysis Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Negative Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Catabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process	Protein Polyubiquitination Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Cycle Checkpoint Cellular Response To Indole-3-methanol Mitotic Nuclear Division Activation Of Anaphase-promoting Complex Activity Salivary Gland Cavitation Protein Localization To Membrane Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Histone H3-K27 Methylation Cell Division Regulation Of Histone H3-K27 Methylation Leukocyte Tethering Or Rolling Negative Regulation Of Cell Aging Ubiquitin-dependent Protein Catabolic Process T Cell Migration Modification-dependent Protein Catabolic Process Regulation Of Branching Involved In Salivary Gland Morphogenesis Intestinal Epithelial Cell Development Single Organismal Cell-cell Adhesion Cellular Response To Lithium Ion Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Protein Localization To Cell Surface Regulation Of Water Loss Via Skin Protein Ubiquitination Intestinal Epithelial Cell Differentiation Heterotypic Cell-cell Adhesion Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Trophectodermal Cell Differentiation Regulation Of Gene Expression By Genetic Imprinting Lymphocyte Migration Mitotic Cell Cycle Process Cellular Extravasation Response To Lithium Ion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Morphogenesis Involved In Differentiation Mitotic Cell Cycle G2 DNA Damage Checkpoint Genetic Imprinting Lens Fiber Cell Differentiation Positive Regulation Of Histone Methylation Positive Regulation Of Transcription Factor Import Into Nucleus Blastocyst Formation Viral Entry Into Host Cell Regulation Of Meiosis Entry Into Host Cell
Tagcloud ?		alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	angptl4 atp5d atp5g3 atp5j2 atp5l ccnb1 cdc10 cdc20 cdc23 dyn efemp1 eng epas1 fbn1 fn1 hcaecs hmox1 itga5 itgav lamr1 lgals3 loxl2 lss p4hb pgk1 pkd2 sage vasodilatory vasoreactive
Tagcloud (Difference) ?		alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	angptl4 atp5d atp5g3 atp5j2 atp5l ccnb1 cdc10 cdc20 cdc23 dyn efemp1 eng epas1 fbn1 fn1 hcaecs hmox1 itga5 itgav lamr1 lgals3 loxl2 lss p4hb pgk1 pkd2 sage vasodilatory vasoreactive
Tagcloud (Intersection) ?